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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Antimicrobial Efficacy of Triclosan- Containing, Herbal and Homeopathy Toothpastes- An Invitro Study
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Comparison of Antimicrobial Efficacy of Triclosan- Containing, Herbal and Homeopathy Toothpastes- An Invitro Study

机译：含三氯生，草药和顺势疗法牙膏的抗菌功效比较-体外研究

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Background: Use of antimicrobial agents is one of the important strategies to prevent oral diseases. These agents vary in their abilities to deliver preventive and therapeutic benefits. Objectives: This invitro study was conducted to assess antimicrobial efficacy of different toothpastes against various oral pathogens. Materials and Methods: A total of nine toothpastes in three groups were tested for their antimicrobial activity against Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Streptococcus mutans (ATCC 0266P) and Candida albicans (Laboratory Strain) by modified agar well diffusion method. Statistical Analysis was performed using Minitab Software. A p-value of less than 0.05 was considered significant. Results: Triclosan-based dental formulation with combination of fluoride (1000ppm) exhibited higher antimicrobial activity against test organisms than the combination of lower fluoride-concentration or sodium monofluorophosphate. Among herbal dentifrices, formulation containing Neem, Pudina, Long, Babool, Turmeric and Vajradanti showed significant antimicrobial activity against all the four tested microorganisms (p<0.05). However, against Streptococcus mutans, all three herbal products showed significant antimicrobial activity. Homeo products showed least antimicrobial activity on the tested strains. Formulation with kreosotum, Plantago major and calendula was significantly effective only against Streptococcus mutans. Conclusion: In the present study, antimicrobial activity of the toothpaste containing both triclosan and fluoride (1000ppm) as active ingredients showed a significant difference (p< 0.05) against all four tested microflora compared to that of with lower fluoride-concentration or sodium monofluorophosphate. Of herbal groups, the only dentifrice containing several phytochemicals was found to be significantly effective and comparable to triclosan-fluoride (1000ppm) formulation. Thus, this herbal toothpaste can be used as alternative to triclosan-based formulations. However, these results might not be clinically useful unless tested invivo.
机译：背景：抗菌药物的使用是预防口腔疾病的重要策略之一。这些药物提供预防和治疗益处的能力各不相同。目的：进行了这项体外研究，以评估不同牙膏对各种口腔病原体的抗菌功效。材料和方法：通过改良的琼脂井对三组中的九种牙膏分别测试了其对大肠杆菌（ATCC 25922），金黄色葡萄球菌（ATCC 25923），变形链球菌（ATCC 0266P）和白色念珠菌（实验室菌株）的抗菌活性。扩散法。使用Minitab软件进行统计分析。小于0.05的p值被认为是重要的。结果：与较低浓度的氟化物或单氟磷酸钠的组合相比，含氟（1000ppm）的三氯生为基础的牙科制剂对测试生物具有更高的抗菌活性。在草药洁齿剂中，含有Neem，Pudina，Long，Babool，姜黄和Vajradanti的配方对所有四种测试微生物均表现出显着的抗菌活性（p <0.05）。然而，针对变形链球菌，所有三种草药产品均显示出显着的抗菌活性。荷马产品对测试菌株显示出最小的抗菌活性。用克氏菌，车前子和金盏花配制仅对变形链球菌有效。结论：在本研究中，与三氟生和氟化物（1000ppm）均为有效成分的牙膏相比，所有四种受试菌群的抗菌活性均与氟化物浓度较低或单氟磷酸钠的相比具有显着差异（p <0.05）。在草药组中，发现唯一含有几种植物化学物质的洁齿剂具有显着的效果，并且与三氯生氟化物（1000ppm）制剂相当。因此，这种草药牙膏可以用作基于三氯生的配方的替代品。但是，除非进行体内测试，否则这些结果可能在临床上无用。

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