...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India
【24h】

Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India

机译：糖化血红蛋白（HbA1c）与非糖尿病患者冠状动脉疾病严重程度的相关性-来自印度东北部的一项基于医院的研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Glycated Hemoglobin (HbA1c) levels are predictive of cardiovascular disease and mortality in patients with diabetes mellitus, however, association of HbA1c with Coronary Artery Disease (CAD) in non-diabetics is inconsistent.Aim: To evaluate the correlation between HbA1c level and severity of CAD in non-diabetic patients using syntatax score in a cohort of proven CAD on angiography at Gauhati Medical College, Guwahati, Assam, India, which is a major tertiary care hospital of North-Eastern India.Materials and Methods: We prospectively collected data of non-diabetic patients with proven CAD on angiography from June 2014 to June 2015. Patients were divided into four groups (interquartiles) according to HbA1c levels, less than 4.8%, 4.8% to 5.1%, 5.1% to 5.6%, and 5.6% to 6.5%. Severity of CAD was assessed using syntatax score and the number of coronary vessels diseased. We compared different quartiles of HbA1c with regard to syntatax score and number of diseased vessels.Results: A total of 346 patients were included in the study. Mean age was 58.1±10.4 years. Of the total 91.9% (318) were males, 44.8% (155) were hypertensives, 29.2% (101) were smokers and 34.7% (120) were dyslipidemic. We found that CAD severity by syntatax score as well as number of vessels involved was significantly different among quartiles (p-values <0.001 and <0.001 respectively). Increase in HbA1c level was strongly correlated with disease severity and higher syntatax score. A significant increase was noted in the mean number of diseased vessels (p-value <0.001) as HbA1c level increases. Age, gender, hypertension and dyslipidemia did not show significant difference among quartiles however smoking was found to be an independent predictor of severity of CAD by syntatax score (p <0.05).Conclusion: From this clinical study, we can conclude that a significant correlation exists between HbA1c and severity of CAD by syntatax score as well as number of vessels involved in non- diabetes.
机译：简介：糖化血红蛋白（HbA1c）水平可预测糖尿病患者的心血管疾病和死亡率，但非糖尿病患者中HbA1c与冠状动脉疾病（CAD）的相关性不一致。目的：评估HbA1c水平与糖尿病之间的相关性在印度阿萨姆邦古瓦哈蒂的Gauhati医学院通过血管造影证实的CAD队列中使用句法评分对非糖尿病患者的CAD严重程度进行分析。材料与方法：我们前瞻性收集2014年6月至2015年6月经血管造影证实具有CAD的非糖尿病患者的数据。根据HbA1c水平将患者分为四组（四分位），分别低于4.8％，4.8％至5.1％，5.1 ％至5.6 ％，以及5.6 ％至6.5 ％。使用句法评分和患病的冠状动脉血管数量评估CAD的严重程度。我们比较了HbA1c不同四分位数的句法评分和患病血管数量。结果：本研究共纳入346名患者。平均年龄为58.1±10.4岁。男性占91.9％（318），高血压占44.8％（155），吸烟者占29.2％（101），血脂异常占34.7％（120）。我们发现，按句法评分的CAD严重程度以及涉及的血管数量在四分位数之间存在显着差异（分别为p值<0.001和<0.001）。 HbA1c水平的升高与疾病的严重程度和较高的句法评分密切相关。随着HbA1c水平的升高，患病血管的平均数量显着增加（p值<0.001）。四分位数之间的年龄，性别，高血压和血脂异常没有显着差异，但是通过句法评分，发现吸烟是CAD严重程度的独立预测因子（p <0.05）。结论：从这项临床研究中，我们可以得出结论，两者之间存在显着相关性在HbA1c和CAD严重程度之间（通过句法评分）以及涉及非糖尿病的血管数量之间存在着联系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号