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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Association of Serum Homocysteine and hs-CRP with Idiopathic Generalised Epilepsy and Duration of Antiepileptic Drug Therapy
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Association of Serum Homocysteine and hs-CRP with Idiopathic Generalised Epilepsy and Duration of Antiepileptic Drug Therapy

机译：血清同型半胱氨酸和hs-CRP与特发性全身性癫痫和抗癫痫药物治疗的持续时间的关系

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Several human and experimental studies have revealed that chronic inflammation may play a vital role in neurodegenerative processes including epilepsy. There is accumulating evidence that inflammatory processes affect the pathophysiology of different epilepsy types.Aim: To assess the concentrations of Homocysteine (Hcy) and High Sensitivity C-Reactive Protein (hs-CRP) in Idiopathic Generalised Epilepsy (IGE) patients and their association with IGE and duration of the Anti Epileptic Drugs (AEDs).Materials and Methods: This case-control study consisted of 100 IGE patients (50 tonic?clonic, 15 absence and 35 myoclonic seizures) and equal number of healthy controls. Hcy levels were assayed by Centaur XP using ADVIA centaur Hcy; whereas hs-CRP levels by ELISA method using commercially available kits.Results: The Hcy and hs-CRP levels were significantly increased in both the patient groups ( 18 years). Significant difference in the levels of Hcy was observed between different epilepsy types of 18 years patients (<0.05). Significantly elevated levels of hs-CRP were noticed in non-responders group compared to responders (<0.05). There was a positive correlation between hs-CRP and Hcy (R2=0.44 and p 5 years) (p=0.002 and p<0.05 respectively) since, AEDs can induce oxidative stress.Conclusion: Hyperhomocysteinaemia (Hyper-Hcy) can induce as well as promote oxidative stress and hence, it can be implicated in neurodegeneration in epilepsy. Elevated levels of hs-CRP in non-responders may be resulted by the contribution of inflammatory pathways in ictogenesis in epileptic tissue, causing intractable epilepsy.
机译：多项人体和实验研究表明，慢性炎症可能在包括癫痫症在内的神经退行性过程中发挥重要作用。有越来越多的证据表明炎症过程会影响不同类型癫痫的病理生理学。目的：评估特发性全身性癫痫（IGE）患者和材料与方法：这项病例对照研究由100名IGE患者组成（50名强直性阵挛，15名失神和35名肌阵挛性癫痫发作）和相同数量的健康人控制。使用ADVIA centaur Hcy通过Centaur XP测定Hcy水平;结果：两个患者组（18岁）的Hcy和hs-CRP水平均显着升高。在18岁患者的不同癫痫类型之间观察到Hcy水平有显着差异（<0.05）。与反应者相比，无反应者组hs-CRP水平显着升高（<0.05）。 hs-CRP与Hcy呈正相关（R2 = 0.44和p 5年）（分别为p = 0.002和p​​ <0.05），因为AEDs可以诱导氧化应激。结论：高同型半胱氨酸血症（Hyper-Hcy）可以诱导并促进氧化应激，因此，它可能与癫痫的神经变性有关。在无反应者中，hs-CRP水平升高可能是由炎性途径在癫痫组织的信息生成中的作用所致，导致了顽固性癫痫。

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