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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Recovery Profile of Atracurium versus Cisatracurium
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Recovery Profile of Atracurium versus Cisatracurium

机译：阿曲库溴铵与顺沙曲库铵的回收率曲线

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Atracurium and cisatracurium are promising drugs offering a predictable recovery due to non-organ dependent elimination. However, due to the variability in metabolism and narrow therapeutic window, monitoring of neuromuscular functions has significant importance.Aim: To compare the onset time, duration of block and recovery indices of atracurium and cisatracurium in equipotent doses. The secondary aim included comparing haemodynamic profile and signs of histamine release.Materials and Methods: The present study was a prospective randomised observational study conducted in the Department of Anaesthesia, Government Medical College, Amritsar, Punjab, India (December 2016 to March 2017). It comprised of 60 ASA Grade I patients in the age group of 18-65 years posted for elective laparoscopic cholecystectomies. Patients were divided into two groups of 30 each. Group C (Cisatracurium) patients received cisatracurium 0.1 mg/kg as loading dose while Group A (Atracurium), patients were administered atracurium 0.5 mg/kg. The onset time, duration of block and recovery index were recorded using Train of Four (TOF) response along with the haemodynamic profile and signs of histamine release, using SPSS 22.0 software considering a p-value<0.05 as significant.Results: The onset time, duration and recovery index in Group A were found to be 168.60±13.44 seconds, 37.12±7.62 minutes and 14.63±1.84 minutes and in Group C, they were recorded to be 181.03±21.76 seconds, 40.37±7.04 minutes and 15.30±1.96 minutes respectively. The haemodynamic profiles in both the groups were comparable and no signs of histamine release were observed.Conclusion: Atracurium has a shorter time of onset as compared to cisatracurium in equipotent dose (2xED95) (p-value<0.01). However, the duration of neuromuscular blockade and the recovery profile of both the drugs were comparable.
机译：阿曲库铵和西沙曲库是有前途的药物，由于非器官依赖性消除作用，可提供可预测的恢复。然而，由于新陈代谢的可变性和狭窄的治疗窗口，对神经肌肉功能的监测具有重要意义。目的：比较等剂量下阿曲库铵和顺沙曲库铵的发作时间，阻断时间和恢复指数。次要目的包括比较血液动力学特征和组胺释放的迹象。材料与方法：本研究是在印度旁遮普邦阿姆利则政府医学院的麻醉科进行的一项前瞻性随机观察性研究（2016年12月至3月） 2017）。它由60位年龄在18-65岁之间的ASAⅠ级患者组成，他们因选择性腹腔镜胆囊切除术而出院。将患者分为两组，每组30名。 C组（Cisatracurium）患者接受西沙曲库铵0.1 mg / kg作为负荷剂量，而A组（Atracurium）的患者接受阿曲库溴铵0.5 mg / kg。使用SPSS 22.0软件（以p值<0.05为显着水平），使用SPSS 22.0软件记录了四次训练（TOF）响应，血流动力学特征和组胺释放的迹象，记录了发作时间，阻塞持续时间和恢复指数。 A组的发作时间，持续时间和恢复指数分别为168.60±13.44秒，37.12±7.62分钟和14.63±1.84分钟; C组为181.03±21.76秒，40.37±7.04分钟和15.30。分别为±1.96分钟。两组的血流动力学特征相当，没有观察到组胺释放的迹象。结论：与等剂量的顺沙曲库铵相比，阿曲库铵的起效时间更短（2xED95）（p值<0.01）。但是，神经肌肉阻滞的持续时间和两种药物的恢复情况是可比的。

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