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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Weight Loss and/or Hypernatraemia in Inadequately Breastfed Term Neonates having Non-haemolytic Unconjugated Hyperbilirubinaemia
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Weight Loss and/or Hypernatraemia in Inadequately Breastfed Term Neonates having Non-haemolytic Unconjugated Hyperbilirubinaemia

机译：具有非溶血性非结合性高胆红素血症的不充分母乳喂养足月新生儿的体重减轻和/或高钠血症

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Introduction: Insufficient breast milk intake can lead to increased incidence of neonatal jaundice, inadequate weight gain, hypernatraemic dehydration in neonates and occasionally may cause serious complications.Aim: To know the proportion of neonates admitted with non-haemolytic unconjugated hyperbilirubinaemia exhibit inadequate weight gain and hypernatraemia and their relationship to breastfeeding pattern.Materials and Methods: We conducted a prospective observational study at the Neonatal Intensive Care Unit (NICU)/Postnatal Care (PNC) ward of our tertiary care hospital, over a period of one year. We enrolled 60 full term neonates with birth weight >2500 gm and >48 hours old, who were admitted for non-haemolytic unconjugated hyperbilirubinaemia. These neonates were evaluated for daily weight, serum sodium levels, mother?s milk sodium levels and breastfeeding patterns. Mean, median and standard deviation were calculated for all the quantitative parameters. The correlations between various study parameters were assessed with the help of chi-square test and Pearson?s correlation coefficient.Results: Analysis revealed that maximum neonates 55 (91.6%) presented with hyperbilirubinaemia in the first week of life and 50 (83%) neonates were on exclusive breastfeeding. There were 21(33%) neonates with significant weight loss of >10% and of these seven (33.3%) had hypernatraemia, whereas in 39 babies who had no significant weight loss only two babies had hypernatraemia. This difference was found to be statistically significant (p-value=0.004). There were high mother?s milk sodium levels in neonates with weight loss and hypernatraemia (p=0.017). Incidence of combined weight loss and hypernatremia among all studied hyperbilirubinemic neonates was 12%. The weight loss pattern in babies was similar in multiparous or primiparous mothers and there was no statistical association of weight loss with parity (43% vs 30% respectively).Conclusion: We observed that a significant proportion of neonates admitted with unconjugated hyperbilirubinaemia which were inadequately breastfed had severe weight loss and hypernatraemia. High mother?s milk sodium levels in subset of babies with severe weight loss can suggest the possibility of lactation failure in their mothers.
机译：简介：母乳摄入不足会导致新生儿黄疸的发生率增加，体重增加不足，新生儿高钠血症性脱水，并可能引起严重的并发症。目的：了解非溶血性非结合性高胆红素血症的新生儿体重增加不足和材料和方法：我们在三级护理医院的新生儿重症监护病房（NICU）/产后保健（PNC）病房进行了为期一年的前瞻性观察研究。我们招募了60名足月新生儿，其出生体重> 2500 gm和> 48小时大，他们因非溶血性非结合性高胆红素血症而入院。对这些新生儿的每日体重，血清钠水平，母乳钠水平和母乳喂养方式进行了评估。计算所有定量参数的平均值，中位数和标准差。通过卡方检验和皮尔森相关系数评估了各种研究参数之间的相关性。结果：分析显示，出生后第一周出现高胆红素血症的新生儿最多（55.91％），出生后第一周出现高胆红素血症的人数最多（50％）（83％）。新生儿仅接受母乳喂养。有21名（33％）的新生儿体重明显减轻> 10％，而这7名（33.3％）的新生儿有高钠血症，而在39名无明显体重减轻的婴儿中，只有两名婴儿有高钠血症。发现该差异在统计学上是显着的（p值＝ 0.004）。在体重减轻和高钠血症的新生儿中，母亲的牛奶钠含量​​较高（p = 0.017）。在所有研究的高胆红素血症新生儿中，体重减轻和高钠血症合并发生率为12％。多胎或初产母亲的婴儿体重减轻模式相似，体重与胎龄之间无统计学关联（分别为43％和30％）。母乳喂养有严重的体重减轻和高钠血症。体重减轻严重的婴儿中，母亲的牛奶钠含量​​较高，可能提示其母亲泌乳失败的可能性。

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