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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Significant Bacterial Islolates in Patients Presenting with Acute Exacerbation of Idiopathic Pulmonary Fibrosis
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Significant Bacterial Islolates in Patients Presenting with Acute Exacerbation of Idiopathic Pulmonary Fibrosis

机译：特发性肺纤维化急性加重患者的重要细菌异物

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Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive, condition that is due to aberrant wound healing response following repetitive alveolar injury. Though traditionally viruses have played a key role in altering the wound healing cascade, the role played by bacteria in the pathogenesis of IPF is unclear. If there is a recurrent bacterial isolate in sputum or bronchial wash, an appropriate antibiotic both prophylactically and therapeutically can help prevent the decline in lung function and morbidity. This is particularly relevant in the treatment since it involves immunosuppressives during exacerbations.Aim: This study analyses the sputum for bacterial isolates in patients with acute exacerbation of IPF and aims to find the significance of such association.Materials and Methods: Sputum samples of 60 patients who came with acute exacerbation of IPF to a Tertiary Medical College and Hospital between February 2015 to March 2016 were analysed. Patients who were unable to produce sputum and who had received antibiotics for the present exacerbation prior to admission were excluded. Expectorated sputum samples were collected in wide mouth sterile containers and were subjected to gram staining and culture using blood agar after assessing the sputum quality. Chi-Square tests were used to find the significant association between the bacterial isolates in the sputum samples.Results: Among the 60 patients, there were isolates in 78.3% (n=47) and rest had no isolates. Streptococcus pneumoniae was isolated in 12 patients and Escherichia Coli in 13 patients and these were found to have significant association statistically in patients presenting with acute exacerbation of IPF. Whereas the rest of the isolates like Klebsiella (n=9), Haemophillus influenza (n=8), Enterococcus (n=2) and Moraxella catarrhalis (n=3) were found to have insignificant association.Conclusion: Preserving the lung functions in patients with IPF is the basis of treatment. Whether infectious causes play a role in attenuating lung function and treating these with prophylactic antibiotics needs to be seen with larger studies in different geographic areas.
机译：特发性肺纤维化（IPF）是一种慢性和进行性疾病，其原因是反复的肺泡损伤后伤口出现了异常的愈合反应。尽管传统上病毒在改变伤口愈合级联中起关键作用，但细菌在IPF发病机理中的作用尚不清楚。如果在痰液或支气管冲洗液中有反复分离的细菌，在预防和治疗上适当的抗生素可帮助预防肺功能和发病率下降。目的：这项研究分析了IPF急性加重患者的痰中细菌分离株，目的是寻找这种关联的意义。材料和方法：分析了2015年2月至2016年3月之间到大专院校和医院的60例IPF急性加重患者的痰标本。不能产生痰并且在入院前因目前病情加重而接受抗生素治疗的患者被排除在外。痰液标本收集在无菌的广口容器中，在评估痰液质量后，使用血琼脂进行革兰氏染色和培养。卡方检验用于发现痰标本中细菌分离株之间的显着相关性。结果：60例患者中，分离株占78.3％（n = 47），其余无分离株。在12例患者中分离出肺炎链球菌，在13例患者中分离出大肠埃希氏菌，在IPF急性加重的患者中，这些在统计学上具有显着相关性。而其余分离株如克雷伯菌（n = 9），流感嗜血杆菌（n = 8），肠球菌（n = 2）和卡他莫拉菌（n = 3）则无明显关联。结论： IPF患者的肺功能是治疗的基础。是否需要在不同地理区域进行较大规模的研究，才能确定传染性原因是否在减弱肺功能方面发挥作用，并用预防性抗生素对其进行治疗。

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