Primary malignancies of Seminal Vesicle (SV) are rare. When involved, it is most commonly due to secondaries or by contiguousspread from adjacent organs. Primary tumours that can arise in SV can be epithelial and mesenchymal. Adenocarcinoma is mostcommon epithelial tumour, and the Clear Cell variant of Adenocarcinoma (CCA) so far has not been reported in literature. PrimarySV malignancies like adenocarcinoma pose a diagnostic dilemma as it becomes diffcult to differentiate it from secondaries or asinvolvement from other adjacent organs even with imaging, histopathology and Immunohistochemistry (IHC). Here we present acase of 34-year-old male who presented with occasional total painless haematuria for four years and was evaluated by ContrastEnhanced Computed Tomography (CECT) which revealed pelvic mass. After evaluation by biopsy, histopathology and IHC he wasdiagnosed as primary clear cell adenocarcinoma. Despite all investigations this malignancy is diffcult to differentiate from mullerianduct cyst carcinoma.
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