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首页> 外文期刊>Journal of bacteriology >Regulation of Penicillinase Synthesis: Evidence for a Unified Model
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Regulation of Penicillinase Synthesis: Evidence for a Unified Model

机译：青霉素酶合成的调节：统一模型的证据。

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摘要

The kinetics of penicillinase induction in Bacillus cereus 569 was investigated. An increase in the rate of penicillinase synthesis was demonstrated within 30 sec of the addition of inducer (benzylpenicillin); however, the maximum induced rate of penicillinase synthesis was not attained until at least 30 min after the addition of inducer. In contrast to earlier claims, a quantitative estimate showed that the penicillinase messenger ribonucleic acid (mRNA) half-life is approximately 2 min. These findings strongly suggest that the rate of synthesis of penicillinase mRNA increases continuously during most of the 30-min latent period. A model for the regulation of penicillinase synthesis in three gram-positive organisms is presented which is consistent with a nondiffusible inducer, a short-lived mRNA, a relatively long latent period (i.e., an apparently slow inactivation of penicillinase repressor), and the existence of at least two regulatory genes.
机译：研究了蜡样芽孢杆菌569中青霉素酶诱导的动力学。加入诱导剂（苄青霉素）后30秒内，青霉素酶的合成速率增加。然而，直到加入诱导剂后至少30分钟才达到青霉素酶合成的最大诱导速率。与以前的权利要求相比，定量估计显示青霉素酶信使核糖核酸（mRNA）的半衰期约为2分钟。这些发现强烈表明，在30分钟的潜伏期中，青霉素酶mRNA的合成速率持续增加。提出了一种在三种革兰氏阳性生物体中调节青霉素酶合成的模型，该模型与不可扩散的诱导剂，短寿的mRNA，相对长的潜伏期（即，青霉素酶阻遏物明显失活）和存在有关。至少两个调节基因。

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