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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Floatation of Decalcified Bone Marrow Core Biopsy ? A Clue to Marrow Hypocellularity
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Floatation of Decalcified Bone Marrow Core Biopsy ? A Clue to Marrow Hypocellularity

机译：脱钙骨髓活检的浮选？骨髓低细胞性的线索

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Background : Examination of bone marrow plays a pivotal role in the practice of haematology. It can be evaluated by three ways ? bone marrow aspiration smears (BMA), bone marrow touch imprints (BMI) and bone marrow biopsy (BMB). BMB sections are considered to be the gold standard for assessing overall marrow cellularity. Aim and Objective: To evaluate the correlation, if any, between bone marrow cellularity and floatation pattern of the core biopsy specimen, after proper decalcification. Setting and Design: This study was carried out in the Department of Pathology, Institute of Medical Sciences, Varanasi over a period of 26 months. Materials and Methods: Specimens of BMA, BMI and BMB were collected from 182 cases. The core biopsy specimens were fixed in 10% buffered formalin for 24 hours, and were decalcified in 5% formic acid for 12 hours. The properly decalcified core biopsy samples were then put into adequate-sized container filled with 10% buffered formalin, and floatation pattern was documented. Statistical Analysis: All the observations were evaluated using simple and basic statistical tools, i.e. sensitivity, specificity, positive predictive value. Chi square test was applied for obtaining statistical correlation i.e. p-value. Results: Out of 182 core biopsy specimens, 32.4% (n=59) floated, while rests sank. Out of the 59 floating core biopsies, 57 were hypocellular. Seven core biopsies, among 123 specimens that sank, were hypocellular. The sensitivity and specificity of floatation pattern for hypocellular marrow were 89.2% and 99.1%, respectively. A strong correlation (p-value <0.001) between the floatation pattern and bone marrow cellularity was obtained. Conclusion: Assessment of floatation pattern of properly decalcified marrow core specimen is reliable for assessing marrow hypocellularity.
机译：背景：骨髓检查在血液学实践中起着举足轻重的作用。可以通过三种方式进行评估吗？骨髓穿刺涂片（BMA），骨髓接触印记（BMI）和骨髓活检（BMB）。 BMB切片被认为是评估整体骨髓细胞性的金标准。目的和目的：评估适当脱钙后骨髓细胞密度与核心活检标本的漂浮模式之间的相关性（如有）。设置与设计：本研究在瓦拉纳西医学科学研究所病理学系进行，历时26个月。资料与方法：收集182例患者的BMA，BMI和BMB标本。将核心活检标本在10％的福尔马林缓冲液中固定24小时，然后在5％的甲酸中脱钙12小时。然后将经过适当脱钙的核心活检样品放入装有10％缓冲福尔马林的适当尺寸的容器中，并记录浮选模式。统计分析：所有观察结果均使用简单且基本的统计工具进行评估，即敏感性，特异性，阳性预测值。卡方检验用于获得统计相关性，即p值。结果：在182例核心活检标本中，有32.4％（n = 59）漂浮，其余部分沉没。在59例浮芯活检中，有57例细胞减少。在123个沉没的标本中，有7个核心活检标本是细胞减少的。漂浮模式对亚细胞骨髓的敏感性和特异性分别为89.2％和99.1％。获得了漂浮模式与骨髓细胞之间的强相关性（p值<0.001）。结论：正确脱钙的髓核标本的漂浮模式的评估对于评估骨髓细胞减少是可靠的。

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