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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity
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Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

机译：印度单纯性超重和肥胖儿童高敏C反应蛋白水平与人体测量和其他代谢指标的关系

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Context: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity.Aim: To study the relationship of hsCRP levels with various anthropometric as well as metabolic parameters in children with simple overweight and obesity. Materials and Methods: This case control study was conducted in Paediatric Endocrinology clinic of a tertiary care hospital in Northern India. Levels of hsCRP were estimated in 100 overweight and obese children (BMI between 85th and 95th percentiles according to age & gender specific CDC 2000 growth charts) aged between 6 and 16 years and in 100 nearly age and sex matched healthy controls. These levels were then correlated to various anthropometric (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist hip ratio, WHR; blood pressure) and biochemical (fasting blood glucose, FBG; total cholesterol, TC; high-density lipoprotein-cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; very low-density lipoprotein-cholesterol, VLDL-C; triglycerides, TG) parameters.Results: Mean levels of hsCRP were significantly higher in the study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to controls. Significantly more (58% versus 10%) subjects in the study group had hsCRP (>3 mg/L). Of all the parameters studied, only BMI showed a positive correlation with hsCRP levels in the study group. Multiple logistic regression analysis for predicting outcome of high hsCRP showed positive correlation with BMI; with every 1 kg/m2 increase in BMI, odds of high hsCRP level were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value <0.0001). Mean values of all the biochemical parameters except HDL-C were significantly higher in the study group.Conclusion: Levels of hsCRP were significantly elevated in overweight and obese children as compared to non-obese children. In addition, these patients also showed abnormalities of lipid and glucose metabolism.
机译：上下文：高敏感性C反应蛋白（hsCRP）水平与肥胖相关的代谢综合征（MS）的其他参数密切相关，可以用作未来心血管疾病风险的预测指标。目的：研究单纯性超重和肥胖儿童的hsCRP水平与各种人体测量学和代谢参数之间的关系。材料和方法：本病例对照研究是在印度北部一家三级护理医院的儿科内分泌诊所进行的。估计有100名6至16岁的超重和肥胖儿童（根据年龄和性别特定的CDC 2000生长图，BMI在85至95％之间）和100名年龄和性别相匹配的健康对照儿童中hsCRP的水平。然后将这些水平与各种人体测量学（体重指数，BMI;腰围，WC;髋围，HC;腰臀比，WHR;血压）和生化指标（空腹血糖，FBG;总胆固醇，TC;高-高密度脂蛋白胆固醇HDL-C;低密度脂蛋白胆固醇LDL-C;极低密度脂蛋白胆固醇VLDL-C;甘油三酸酯TG）与对照相比（3.92±2.20对2.15±1.05 mg / L）。研究组中有更多的受试者（58％相对于10％）具有hsCRP（> 3 mg / L）。在所有研究的参数中，只有BMI与研究组的hsCRP水平呈正相关。多元logistic回归分析预测高hsCRP的结果与BMI呈正相关。随着BMI每增加1 kg / m2，高hsCRP水平的几率增加37％（OR = 1.37; 95％CI 1.23-1.53​​，p值<0.0001）。研究组除HDL-C外的所有生化指标均值均较高。结论：与非肥胖儿童相比，超重和肥胖儿童的hsCRP水平显着升高。此外，这些患者还表现出脂质和葡萄糖代谢异常。

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