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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of Cytochrome Modulators in Altering the Occurrence of Cataract in Rats
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Role of Cytochrome Modulators in Altering the Occurrence of Cataract in Rats

机译：细胞色素调节剂在改变大鼠白内障发生中的作用

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Background: Cataract is one of the primary causes of blindness all over the world. It indicates the onset of secondary complications of diabetes. The only treatment available is surgery as there are no satisfactory drugs which can prevent or retard the initiation and maturation of cataract. It was hypothesized that cytochrome P 450 (CYP) inducers or inhibitors can modify the cataract occurrence by accelerating or delaying the occurrence of cataract respectively. Objective: To study the effect of two commonly used drugs, phenytoin (CYP inducer) and ciprofloxacin (CYP inhibitor) on the initiation and maturation of cataract with the galactose- induced cataract model. Materials and Methods: The experiment was conducted in 24 new born male Wistar rats. Cataract formation was induced with a 50% galactose diet. The rats were randomized into four groups of 6 rats each: Group 1 rats received a normal diet; Group 2, 3 and 4 rats received 50% galactose diet day 23 onwards. In addition, Group 3 rats were pre-treated with ciprofloxacin (20mg/kg) and Group 4 rats were pre-treated with phenytoin (50mg/kg) day 18 onwards once a day orally. The appearance of cataract was checked daily with an ophthalmoscope. The maturation pattern was examined using Fundus Fluorsen Angiographer (FFA). The cataract was graded according to Sippel s classification. The experimental and control groups were compared by chi square test and the results were considered significant at p< 0.05. Results: The initiation of cataract was significantly delayed with ciprofloxacin as compared to galactose; however, there was no difference in the maturation pattern of cataract in both the groups. In spite of being a CYP inducer, the initiation of cataract was not accelerated in phenytoin group. Rather, it was significantly delayed and the cataract did not progress to stage 5 even on 30th day of galactose administration Conclusion: CYP450 modulators have a significant effect on the initiation of cataract without significantly altering the maturation pattern. It is not reasonable to extrapolate the results of one enzyme inhibitor or inducer to other CYP modulators. Hence, further studies are needed to identify the pharmacological profile of various CYP modulators on the occurrence of cataractogenesis.
机译：背景：白内障是全世界失明的主要原因之一。它表明糖尿病继发性并发症的发作。唯一可用的治疗方法是手术，因为没有令人满意的药物可以预防或延缓白内障的发作和成熟。假设细胞色素P 450（CYP）诱导剂或抑制剂可以通过加速或延迟白内障的发生来分别改变白内障的发生。目的：研究半乳糖诱导的白内障模型对苯妥英（CYP诱导剂）和环丙沙星（CYP抑制剂）两种常用药物对白内障的引发和成熟的影响。材料与方法：实验是在24只新生的雄性Wistar大鼠中进行的。用50％的半乳糖饮食诱导白内障形成。将大鼠随机分为四组，每组六只大鼠：第一组大鼠接受正常饮食;第2、3和4组大鼠从第23天开始接受50％的半乳糖饮食。此外，第18组开始于第18天起口服环丙沙星（20mg / kg）预处理，第4组大鼠经苯妥英钠（50mg / kg）进行预处理。每天用检眼镜检查白内障的外观。使用眼底荧光血管造影仪（FFA）检查成熟模式。根据Sippel的分类对白内障进行分级。通过卡方检验比较实验组和对照组，结果被认为在p <0.05时具有显着性。结果：与半乳糖相比，环丙沙星显着延迟了白内障的发作;然而，两组的白内障成熟方式没有差异。尽管是CYP诱导剂，但苯妥英钠组白内障的发生并未加速。相反，它被显着延迟，并且即使在半乳糖给药的第30天，白内障也不会进展到第5阶段。结论：CYP450调节剂对白内障的发生有显着影响，而不会显着改变成熟模式。将一种酶抑制剂或诱导剂的结果外推至其他CYP调节剂是不合理的。因此，需要进一步的研究来鉴定各种CYP调节剂对白内障发生的药理作用。

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