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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Antibacterial Efficacy of MTA with and without Additives Like Silver Zeolite and Chlorhexidine
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Evaluation of Antibacterial Efficacy of MTA with and without Additives Like Silver Zeolite and Chlorhexidine

机译：含和不含银沸石和洗必泰等添加剂的MTA的抗菌效果评估

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Introduction: Microorganisms, predominantly Enterococcus faecalis are found responsible in the progression of pulpal, periradicular diseases and in endodontic failures. Unsuccessful conventional treatment might necessitate the need for a surgical approach; where in retrograde restorative materials are used to seal the apex. Among the root end filling materials, Mineral Trioxide Aggregate (MTA) is considered biocompatible and is most commonly used in clinical applications but it has limited antibacterial activity. Metallic silver and chlorhexidine have been added into various dental materials to enhance the antibacterial activity. Aim: This study aimed to compare the antibacterial effect of MTA, MTA mixed with silver zeolite and MTA mixed with chlorhexidine against Enterococcus faecalis. Materials and Methods: Test materials used in the study were divided into three groups namely Group 1- MTA , Group 2-MTA + Silver Zeolite , Group 3-MTA + Chlorhexidine. Direct contact test was done by placing a standardized suspension of Enterococcus faecalis on the test materials in a 96 well microtiter plate. The bacterial growth was measured spectrophotometrically using ELISA reader at intervals of one, three and seven days. Statistical Analysis: Data was collected by recording the optical density and analyzed using two-way ANOVA and Tukey?s multiple post hoc test followed by paired-t test. Results and Conclusion: All test groups showed antibacterial activity against Enterococcus faecalis at day one, three and seven. MTA with silver zeolite showed the maximum antibacterial activity followed by MTA with 2% chlorhexidine. The least antibacterial effect was shown by MTA mixed with sterile water.
机译：简介：微生物（主要是粪肠球菌）被发现与牙髓，根尖周疾病的发展以及牙髓衰竭有关。常规治疗不成功可能需要手术治疗。在逆行的地方，用修复材料密封顶端。在根端填充材料中，三氧化二矿骨料（MTA）被认为具有生物相容性，最常用于临床，但其抗菌活性有限。金属银和洗必泰已被添加到各种牙科材料中以增强抗菌活性。目的：本研究旨在比较MTA，MTA与银沸石混合以及MTA与洗必泰混合对粪肠球菌的抗菌作用。材料和方法：研究中使用的测试材料分为三组，分别为1-MTA组，2-MTA组+银沸石，3-MTA组+洗必太。通过将粪肠球菌的标准悬浮液放置在96孔微量滴定板中的测试材料上进行直接接触测试。使用ELISA读数器以1天，3天和7天的间隔分光光度法测量细菌的生长。统计分析：通过记录光密度收集数据，并使用双向ANOVA和Tukey的多次事后检验，然后进行配对t检验进行分析。结果与结论：所有试验组在第1、3和7天均表现出对粪肠球菌的抗菌活性。含银沸石的MTA表现出最大的抗菌活性，其次是含2％洗必泰的MTA。 MTA与无菌水混合显示最小的抗菌作用。

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