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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of HRCT Chest in Post Stem Cell Transplant Recipients Suspected of Pulmonary Complications
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Role of HRCT Chest in Post Stem Cell Transplant Recipients Suspected of Pulmonary Complications

机译：HRCT胸部在疑似肺部并发症的干细胞移植后接受者中的作用

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Introduction: Stem cell transplantation is today?s procedure of choice for management of various hematopoietic malignant and severe immunogenic disorders. High Resolution Computed Tomography (HRCT) is a common technique for the diagnosis of pulmonary complications in stem cell transplant recipients. There are a large number of complications which can complicate the post-transplant period.Aim: To study the role of HRCT chest in stem cell transplant patients developing pulmonary complications, detect any evidence of infection, detect clinical signs of lung infections, Graft versus Host Disease (GvHD) or other regimen related toxicities outlined earlier, detect any evidence of GvHD and correlate these clinical signs with radiological changes in the lungs.Materials and Methods: The study was a prospective study of 52 participants with indication of stem cell transplantation. The study included recipients of HSCT transplant and the exclusion criteria was patients who failed for engraftment and having an associated history of pulmonary embolism. Patients were screened for pre-transplant chemotherapy, clinical examination, laboratory investigations including blood and biochemical examinations, imaging by ultrasound, chest radiography, baseline HRCT and a follow-up for post-transplant infections and complications with 16 slice Siemens CT scan. Statistical analysis was done using Pearson's chi-squared test.Results: Four patients among the total 56 were excluded due to non-engraftment. The most common associated findings in decreasing order are (these patients died): consolidation, pancytopenia and gastrointestinal tract symptoms with VOD (Veno-Occlusive Disease). These findings were seen on HRCT as consolidation, cavities, ground glass opacities, fibrotic changes, bronchiectatic changes and tree in bud appearance.Conclusion: The study highlights the significant positive findings on the HRCT which were missed on routine chest radiograph and can be used for early diagnoses. Thus, HRCT helped in decreasing the mortality. The abnormal vitals and TLC counts showed a significant relation between the numbers of death in the study.
机译：简介：干细胞移植是当今管理各种造血系统恶性和严重免疫原性疾病的首选程序。高分辨率计算机断层扫描（HRCT）是诊断干细胞移植受者肺部并发症的常用技术。目的：研究HRCT胸部在干细胞移植患者发生肺部并发症中的作用，检测感染的任何证据，检测肺部感染的临床体征，嫁接与宿主之间的关系。疾病（GvHD）或之前概述的其他与方案相关的毒性反应，可以检测到任何GvHD证据，并将这些临床体征与肺部放射学改变相关联。该研究包括HSCT移植的接受者，排除标准是移植失败并伴有肺栓塞病史的患者。对患者进行了移植前化疗，临床检查，包括血液和生化检查在内的实验室检查，超声成像，胸部放射线照相，基线HRCT以及16层Siemens CT扫描对移植后感染和并发症的随访。结果：在全部56例患者中有4例由于未植入而被排除在外。降序最常见的相关发现是（这些患者死亡）：合并，全血细胞减少症和胃肠道症状伴VOD（静脉阻塞性疾病）。这些发现在HRCT上表现为固结，腔，玻璃不透明，纤维化，支气管扩张和树芽状。早期诊断。因此，HRCT帮助降低了死亡率。异常的生命力和TLC计数显示了研究中死亡人数之间的显着相关性。

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