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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Antibacterial Effect of Aloe Vera Gel against Oral Pathogens: An In-vitro Study
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Antibacterial Effect of Aloe Vera Gel against Oral Pathogens: An In-vitro Study

机译：芦荟凝胶对口腔病原菌的抗菌作用：一项体外研究

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Introduction: Natural herbal remedies have shown promising anti-microbial property and fewer side effects compared to synthetic anti-microbial therapy. Aloe Vera is a medicinal plant used for management of various infections since ancient times as it has anti-inflammatory, anti-microbial, and immune-boosting properties.Aim: The aim of the present study was to determine the anti-microbial and inhibitory activities of various concentration of Aloe Vera Gel (AVG) against oral pathogenic bacteria.Materials and Methods: Subgingival calculus and aspiration of periapical abscess and periodontal abscess was done in 20 patients and the sample transferred to thioglycolate broth, which was incubated in Mutans Sanguis agar, blood agar and cultured in anaerobic gas chamber. The colonies formed were identified further by gram staining methods and biochemical fermentation tests (IMViC). Each isolated colony of identified bacteria were cultured separately in Muller-Hilton broth and incubated at 37°C for 24 hours. Anti-microbial activity of the AVG was tested by the disc diffusion method and minimum inhibitory concentration was determined by broth micro-dilution method.Result: Various staining and biochemical tests confirmed that the sample contained Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans), Clostridium bacilli (C. bacilli), Streptcoccus mutans (S. mutans) and Staphlococcus aureus (Staph. aureus). AVG showed anti-bacterial property at 100% and 50% concentration (?t? value = 7.504, p-value <0.001). At lower concentration there was no effect against the bacteria. At 100% AVG concentration, zone of inhibition measured was 6.9mm in A. actinomycetemcomitans, 6.3mm in C. bacilli, 6.8mm in S. mutans and 6.6mm in Staph. aureus. The standard drugs were also used to compare anti-bacterial property of AVG. Result showed that higher concentration (100%, 50%) of AVG has comparable zone of inhibition with Ofloxacin (5mcg) and Ciprofloxacin (30mcg).Conclusion: AVG at higher concentration showed anti-bacterial property and can be used as a promising adjunct for oral health care.
机译：简介：与合成抗微生物疗法相比，天然草药已显示出令人鼓舞的抗微生物特性，且副作用更少。芦荟自古以来就是一种用于处理各种感染的药用植物，因为它具有抗炎，抗微生物和增强免疫力的作用。目的：本研究的目的是确定抗微生物和抑制活性材料和方法：对20例患者进行了龈下结石以及根尖周脓肿和牙周脓肿的抽吸，并将样品转移到巯基乙酸盐肉汤中，并在Mutans Sanguis琼脂中孵育，血琼脂并在厌氧气室内培养。通过革兰氏染色法和生化发酵试验（IMViC）进一步鉴定形成的菌落。在Muller-Hilton肉汤中分别培养鉴定出的细菌的每个菌落，并在37°C下孵育24小时。通过椎间盘扩散法检测AVG的抗微生物活性，并通过肉汤微量稀释法测定其最低抑菌浓度。结果：各种染色和生化测试均证实样品中包含放线杆菌，放线杆菌（A. actinomycetemcomitans），梭状芽胞杆菌（杆菌），变形链球菌（S. mutans）和金黄色葡萄球菌（Staph。aureus）。 AVG在浓度为100％和50％时显示出抗菌性能（Δt值= 7.504，p值<0.001）。在较低浓度下，对细菌没有作用。在AVG浓度为100％时，测得的抑制区在放线杆菌中为6.9mm，在杆菌中为6.3mm，在变形链球菌中为6.8mm，葡萄球菌中为6.6mm。金黄色的。标准药物也用于比较AVG的抗菌性能。结果表明，较高浓度（100％，50％）的AVG具有与氧氟沙星（5mcg）和环丙沙星（30mcg）相当的抑制范围。结论：较高浓度的AVG具有抗菌性能，可以用作口腔保健的有希望的辅助手段。

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