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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Alcohol and Drug Use in Injured Drivers ? An Emergency Room Study in a Regional Tertiary Care Centre of North West India
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Alcohol and Drug Use in Injured Drivers ? An Emergency Room Study in a Regional Tertiary Care Centre of North West India

机译：酒精和毒品在受伤的驾驶员中的使用？印度西北部地区三级医疗中心的急诊室研究

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Introduction: Chronic hyperglycaemia in type 2 diabetes, effects the central nervous system by altering the concentrations of brain metabolites like N-acetyl aspartate (NAA) and myoinositol (mI), which are indicators of neuronal integrity and glial cell damage respectively. Dorsolateral frontal lobe is associated with aspects of cognition especially right frontal lobe is involved in episodic memory retrieval, ninety percent of the diabetic cases are type 2 in nature globally and yoga is very effective in stabilizing the brain metabolites by bringing the blood glucose levels to near or within the physiological range in type 2 diabetes. Aim and Objectives: The aim of the study was to observe the effects of yogasana and pranayama on glycosilated haemoglobin (HbA1c) levels and right dorsolateral frontal cortical NAA and mI concentration in type 2 diabetic subjects. Materials and Methods: It?s a case control study. Sixty eight type 2 diabetic subjects of both the sex, aged between 35-65 years are included in the study, subjects are divided in to test and control group 34 each. Test group subjects did the yogasana and pranayama for a period of 6 months, 6 days in a week, 45-60 minutes daily under the supervision of a qualified yoga teacher. Control group subjects are not on any specific exercise regimen. Both the group subjects are taking oral hypoglycaemic agents. HbA1c levels are measured using the Bio-Rad D-10? haemoglobin A1c program and Magnetic Resonance Spectroscopy (MRS) is used in assessing the metabolite concentrations. Statistical analysis: Analysis of data was done by using unpaired t-test. P-value for HbA1c level is <0.001, which is highly significant statistically. P-value for NAA was < 0.02 and for myoinositol was < 0.01, which are statistically significant. Results : HbA1c levels in control and test group subjects are 7.7 ± 1.84 and 6.02 ± 0.46 respectively. NAA concentrations in the right dorsolateral frontal lobe of control and test group are 1.44 ± 0.15 and 1.54 ± 0.19 respectively. The mI concentrations in the right dorsolateral frontal lobe of control and test group are 0.61 ± 0.22 and 0.47 ± 0.24 respectively. Conclusion: Yogasana and pranayama minimized the neuronal and glial cellular damage in test group, which is evident by minimal changes in right dorsolateral frontal lobe NAA and mI levels in type 2 diabetic subjects.
机译：简介：2型糖尿病的慢性高血糖症通过改变脑代谢产物（例如N-乙酰天门冬氨酸（NAA）和肌醇（mI））的浓度来影响中枢神经系统，这分别是神经元完整性和神经胶质细胞损伤的指标。背外侧额叶与认知方面有关，尤其是右额叶参与情节性记忆恢复，全球90％的糖尿病病例为2型，瑜伽通过使血糖水平接近于稳定脑代谢物非常有效。或在2型糖尿病的生理范围内。目的和目的：本研究的目的是观察2型糖尿病受试者中Yogasana和pranayama对糖化血红蛋白（HbA1c）水平以及右后外侧额叶皮质NAA和mI浓度的影响。材料和方法：这是一个病例对照研究。该研究包括年龄在35-65岁之间的六十八名男女两性的2型糖尿病受试者，受试者分别分为测试组和对照组34。测试组的受试者在合格的瑜伽老师的指导下进行了6个月，每周6天，每天45-60分钟的Yogasana和pranayama训练。对照组受试者没有任何特定的运动方案。两组受试者都在服用口服降糖药。使用Bio-Rad D-10？测量HbA1c水平。血红蛋白A1c程序和磁共振波谱（MRS）用于评估代谢物浓度。统计分析：数据分析通过不配对t检验进行。 HbA1c水平的P值<0.001，在统计学上非常显着。 NAA的P值<0.02，而肌醇的P值<0.01，具有统计学意义。结果：对照组和测试组受试者的HbA1c水平分别为7.7±1.84和6.02±0.46。对照组和试验组右背外侧额叶的NAA浓度分别为1.44±0.15和1.54±0.19。对照组和测试组右背外侧额叶的mI浓度分别为0.61±0.22和0.47±0.24。结论：Yogasana和pranayama将测试组的神经元和神经胶质细胞损伤减至最小，这在2型糖尿病受试者的右后外侧额叶NAA和mI水平的变化很小的情况下很明显。

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