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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Salivary Levels of Pyridinoline Cross Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) in Periodontal Health and Disease
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Evaluation of Salivary Levels of Pyridinoline Cross Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) in Periodontal Health and Disease

机译：唾液中吡y啉交联的羧型端粒I型胶原（ICTP）在牙周健康和疾病中的评估

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Background: Traditional parameters (Pocket depth, bleeding on probing, clinical attachment loss, radiographic findings) have been used for a long time for the assessment of periodontal disease conditions. However, these parameters only indicate towards the periodontal damage that has already taken place but do not give any idea regarding the current status of the periodontal health or disease. Hence, the present study is aimed at evaluating the concentration of the bone biomarker ICTP in saliva, which can give a better real time assessment of periodontal health and disease. Materials and Methods: Forty three patients were selected and divided into three groups based on the recorded clinical parameters of probing pocket depth, attachment loss and bleeding on probing. Group I (Healthy, n = 11), Group II (Gingivitis, n = 17), Group III (Periodontitis. n = 15). Salivary samples were collected before scaling and root planning to avoid contamination by blood. ICTP levels were evaluated in the salivary samples by using enzyme linked immunosorbent assay (ELISA). Statistical analysis used: Kruskal Wallis test was used to compare the mean ICTP level of the three groups. Results: ICTP was detected in all the samples. Highest mean ICTP concentrations in saliva were obtained for group III (periodontitis group) and the lowest mean ICTP concentrations were seen in group I (healthy group). This suggests that the level of ICTP in saliva increases proportionally from periodontal health to diseased conditions (gingivitis & periodontitis). Conclusion: There is a substantial increase in the salivary concentration of ICTP in chronic periodontitis patients than in gingivitis and healthy patients. Salivary ICTP levels were the maximum in chronic periodontitis patients followed by gingivitis patients and the least in healthy individuals. ICTP may be considered as a biomarker in periodontal disease progression.
机译：背景：传统参数（口袋深度，探查出血，临床附件丢失，影像学发现）已长期用于评估牙周疾病状况。然而，这些参数仅指示已经发生的牙周损伤，而没有给出关于牙周健康或疾病的当前状态的任何想法。因此，本研究旨在评估唾液中骨生物标志物ICTP的浓度，可以更好地实时评估牙周健康和疾病。材料与方法：根据记录的探查袋深，探查附件丢失和出血的临床参数，选择43例患者，分为三组。第一组（健康，n = 11），第二组（牙龈炎，n = 17），第三组（牙周炎，n = 15）。在进行结垢和根部计划之前，应收集唾液样本，以避免血液污染。使用酶联免疫吸附测定（ELISA）评估唾液样品中的ICTP水平。使用的统计分析：使用Kruskal Wallis检验比较三组的平均ICTP水平。结果：所有样品中均检出了ICTP。 III组（牙周炎组）的唾液中ICTP的平均浓度最高，而I组（健康组）的ICTP浓度最低。这表明，从牙周健康到疾病状况（牙龈炎和牙周炎），唾液中ICTP的含量成比例增加。结论：与牙龈炎和健康患者相比，慢性牙周炎患者唾液中ICTP的浓度显着增加。慢性牙周炎患者的唾液ICTP水平最高，其次是牙龈炎患者，健康个体最低。 ICTP可被认为是牙周疾病进展的生物标志物。

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