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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Does Vitamin D Supplementation Improve Glycaemic Control In Children With Type 1 Diabetes Mellitus? ? A Randomized Controlled Trial SC15-SC17
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Does Vitamin D Supplementation Improve Glycaemic Control In Children With Type 1 Diabetes Mellitus? ? A Randomized Controlled Trial SC15-SC17

机译：补充维生素D是否能改善1型糖尿病儿童的血糖控制？ ？随机对照试验SC15-SC17

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Introduction: Vitamin D endocrine system is a potential immune system modulator and has been implicated in the pathogenesis of several autoimmune diseases including Type 1 Diabetes Mellitus (T1DM). Studies have demonstrated an inverse risk relationship between T1DM and Vitamin D levels and also, shown a reduced risk of the disease with its supplementation.Aim: To evaluate the role of Vitamin D as an adjuvant in improving glycaemic control and residual pancreatic beta-cell function.Primary outcome was the mean change in HbA1c levels over a period of six months.Materials and Methods: This double-blinded randomized controlled trial was done in a tertiary care hospital, Southern India and included 52 children aged 1-18 years with T1DM, with 26 participants each in the intervention and standard of care arm. Oral Vitamin D therapy was administered once a month for six months in addition to insulin in intervention arm while only insulin was continued for other arm. Plasma HbA1c, serum 25-Hydroxy vitamin D (25OHD), insulin dose and C-peptide were measured at baseline and repeated after 6 months.Results: Prevalence of Vitamin D deficiency was as high as 63.5% i.e., 33 of total 52 children with T1DM. The mean C-peptide levels were significantly high in intervention arm as compared to standard of care after six months. However, there was no significant difference in HbA1c, and insulin requirement at six months between the two groups. No adverse events due to Vitamin D therapy were noted.Conclusion: Oral Vitamin D may serve as an adjuvant to insulin therapy for children with T1DM by augmenting residual beta-cell function and improving insulin secretion. However, a significant decrease in HbA1c level and requirement for exogenous insulin was not achieved in our study.
机译：简介：维生素D内分泌系统是一种潜在的免疫系统调节剂，与多种自身免疫性疾病（包括1型糖尿病（T1DM））的发病机理有关。研究已经证明T1DM与维生素D水平之间存在负风险关系，并且补充维生素D可以降低疾病的风险。主要结果是六个月期间HbA1c水平的平均变化。材料和方法：这项双盲随机对照试验是在印度南部的一家三级医院进行的，其中包括52名1-18岁的T1DM儿童，有26名参与者分别参加了干预和护理标准部门。除干预组的胰岛素外，还每月口服一次维生素D治疗，共六个月，而另一组仅继续使用胰岛素。在基线时测量血浆HbA1c，血清25-羟维生素D（25OHD），胰岛素剂量和C肽，并在6个月后重复进行。结果：维生素D缺乏症的患病率高达63.5％，即52例儿童中的33例T1DM。与六个月后的护理标准相比，干预组的平均C肽水平显着较高。但是，两组之间在六个月时的HbA1c和胰岛素需求量均无显着差异。结论：口服维生素D可通过增加残余β细胞功能并改善胰岛素分泌，为T1DM患儿胰岛素治疗提供佐剂。但是，在我们的研究中并未实现HbA1c水平的显着降低和对外源性胰岛素的需求。

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