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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Ciprofloxacin Induced Stevens-Johnson Syndrome
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Ciprofloxacin Induced Stevens-Johnson Syndrome

机译：环丙沙星诱发史蒂文斯-约翰逊综合征

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A 65-year-old man was admitted to the hospital with high gradefever, loose stools and exfoliated hyperpigmented skin. His pasthistory revealed that he had consulted a Registered MedicalPractitioner (RMP) with the chief complaints of loose stools,vomiting and fever. He was then prescribed Cipro?oxacin 500 mgand Tinidazole 600 mg. Later, he observed hyper pigmented areasand some blebs over the skin, half an hour following administrationof the same drug. Gradually, by the next morning, the pigmentationspread all over the body and the blebs increased in size. Then, hewas rushed to a government hospital where he was administeredRinger Lactate (RL), Dextrose Normal Saline (DNS), IV CIFRAN(Cipro?oxacin), injection RANTAC (ranitidine), injection Diclofenac,injection Paracetamol, injection PIPTAZ (Pipercillin+Tazobactam)IV BD. Following administration of these drugs, he experiencedpainful exfoliation of skin [Table/Fig-1,2]. Due to administration of IVCIFRAN, the problem further aggravated. The causality assessmentwas carried out using Naranjo scale. The obtained causality scorewas 10. Causal relationship was found to be “Defnite” as perNaranjo scale [Table/Fig-3]. Laboratory fndings indicated that urinemyoglobin was positive, LDH and SGOT were abnormally elevatedwhereas, serum creatinine and urea levels were moderately elevated[Table/Fig-4].
机译：一名65岁的男子因高烧，大便稀疏和色素沉着脱落而入院。他的历史记录表明，他曾就粪便松散，呕吐和发烧的主要症状咨询过注册医生（RMP）。然后给他开了500毫克环丙沙星和600毫克替硝唑。后来，在服用相同药物的半小时后，他观察到皮肤上色素沉着的区域和一些气泡。逐渐地，到第二天早晨，色素沉着遍及全身，并且气泡的大小增加。然后，他被送往一家公立医院，接受了林格乳酸（RL），右旋葡萄糖生理盐水（DNS），静脉注射CIFRAN（环丙沙星），兰特酸（雷尼替丁）注射液，双氯芬酸，对乙酰氨基酚注射液，PIPTAZ（Pipercillin + Tazobactam）注射IV BD。服用这些药物后，他经历了皮肤的痛苦剥离[表/图-1,2]。由于使用了IVICFRAN，该问题进一步恶化。使用Naranjo量表进行因果关系评估。获得的因果关系得分为10。因果关系按纳兰霍量表为“ Defnite” [表/图3]。实验室检查发现，尿肌红蛋白呈阳性，LDH和SGOT异常升高，而血清肌酐和尿素水平适度升高[表/图4]。

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