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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Oral Mucosal Lesions Associated with Smokers and Chewers ? A Case-Control Study in Chennai Population
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Oral Mucosal Lesions Associated with Smokers and Chewers ? A Case-Control Study in Chennai Population

机译：与吸烟者和咀嚼者有关的口腔粘膜病变？钦奈人群的病例对照研究

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Aims and Objectives: To determine the association of oral mucosal lesions in a group of Chennai population aged 15 years and above with smoking and chewing habits. To also determine the dose-response relationship of these habits associated with the risk of oral mucosal lesions. Materiala and Methods: The study was undertaken with 450 subjects with smoking and/or chewing habits aged 15 years and over gathered through random selection in Chennai, India. Subjects with alcohol intake were excluded from the study. Based on the habits the study group was categorized into smokers, chewers and mixed (smoking+chewing). One hundred and fifty subjects diagnosed with oral mucosal lesions designated as ?cases? and 300 lesion-free ?controls?, frequency matched for age, sex, habit and family income were assessed during the study. The study protocol included a visual oral soft tissue examination and a questionnaire-based interview. In addition, those requiring further examination, scalpel biopsies were performed to establish a definitive diagnosis. Results: Irrespective of the type of habit, 78% of cases smoked and/or chewed for more than 10 years as compared to 37.4% of the control group. Similarly, 71.3% of cases smoked and/or chewed more than 5 times per day as compared to 25.6% of the control group. Eleven habits related mucosal lesions of the oral cavity were encountered. Smoker?s melanosis was the most common oral mucosal lesion followed by Oral submucous fibrosis and Leukoplakia. Dose-response relationships were observed for both duration and frequency of habits on the risk of oral mucosal lesions. Conclusion: The result of the present study provides information on the association of oral mucosal lesions in smokers, chewers and patients with mixed habits. The mucosal lesions encountered included a few potentially malignant conditions and oral squamous cell carcinoma. Habits were more prevalent in men thus more lesions were encountered in males than in females. Moreover, increase in the duration and frequency of habits was significant predictors of risk in the case population.
机译：目的和目的：确定一组年龄在15岁及以上的钦奈人群口腔黏膜病变与吸烟和咀嚼习惯的关系。还应确定这些习惯与口腔粘膜病变风险相关的剂量反应关系。材料和方法：该研究是通过对印度钦奈市的450名具有15岁及15岁以上吸烟和/或咀嚼习惯的受试者进行的随机选择而收集的。具有酒精摄入量的受试者被排除在研究之外。根据习惯将研究小组分为吸烟者，咀嚼者和混合（吸烟+咀嚼）人群。 150名被诊断患有口腔粘膜病变的受试者称为“病例”。在研究期间评估了300个无病灶“对照”，这些频率与年龄，性别，习惯和家庭收入相匹配。研究方案包括视觉口腔软组织检查和基于问卷的访谈。此外，对于那些需要进一步检查的患者，还需进行手术刀活检以确诊。结果：与习惯类型无关，吸烟和/或咀嚼超过10年的病例占78％，而对照组为37.4％。同样，每天抽烟和/或咀嚼5次以上的病例为71.3％，而对照组为25.6％。遇到了11种与习惯有关的口腔粘膜病变。吸烟者的黑变病是最常见的口腔粘膜病变，其次是口腔粘膜下纤维化和白斑。观察到持续时间和习惯频率与口腔粘膜病变风险的剂量反应关系。结论：本研究的结果提供了有关吸烟者，咀嚼者和混合生活习惯患者口腔粘膜病变的相关信息。遇到的粘膜病变包括一些潜在的恶性疾病和口腔鳞状细胞癌。习惯在男性中更为普遍，因此男性比女性遭受更多的损害。此外，习惯持续时间和频率的增加是该病例人群中危险的重要预测指标。

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