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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of Prophylactic Tranexamic Acid in Reducing Blood Loss during Elective Caesarean Section: A RandomizedControlled Study
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Role of Prophylactic Tranexamic Acid in Reducing Blood Loss during Elective Caesarean Section: A RandomizedControlled Study

机译：预防性氨甲环酸在选择性剖宫产术中减少失血的作用：一项随机对照研究

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Introduction: Obstetric haemorrhage accounts for 20-25% of maternal mortality and morbidity. Anti-fibrinolytics are being widely used in field of surgery. It is also used to reduce heavy menstrual blood loss.Aim: To analyse the effectiveness of Tranexamic Acid (TXA) in reducing blood loss during elective caesarean section.Materials and Methods: This interventional, randomized, parallel group study was done in the Department of Obstetrics and Gynaecolgy, PSG IMSR, Coimbatore, from June 2014 to May 2015. It was conducted on 120 women undergoing caesarean section. They were allocated to either Study or Control group by computer generated random number tables. TXA was given prior to surgery in study group in addition to the routine care {10 units of oxytocin added to the intravenous drip soon after baby delivery} whereas, the control group had routine care alone. Blood loss was measured in both groups by gravimetric method. Haemoglobin before and after surgery was estimated and the percentage of difference was compared.Statistical analysis: Primary outcome variables were volume of blood loss and percentage fall in haemoglobin before and after surgery. Secondary outcomes were duration of surgery, proportion of subjects with >500ml of blood loss, need for additional uterotonics and side effects. Unpaired t-test and Chi-square test were used to compare the outcome variables.Results: There was significant reduction in blood loss calculated from placental delivery till end of surgery: 347.16ml in study group versus 517.72ml in control group (p<0.01). Another parameter studied was the percentage of fall in haemoglobin before and after surgery and the number of subjects who had more than 10% fall in haemoglobin. 9.3% of subjects in study group and 39% of subjects in control group had more than 10% fall in haemoglobin (p<0.01). There were no immediate post-operative complications to the mother and neonate.Conclusion: TXA significantly reduced the amount of blood loss during Lower Segment Caesarean Section (LSCS). Use of TXA was not associated with adverse effects. Thus, TXA can be used safely and effectively in subjects undergoing LSCS.
机译：简介：产科出血占产妇死亡率和发病率的20-25％。抗纤维蛋白溶解剂被广泛用于外科手术领域。目的：分析氨甲环酸（TXA）在选择性剖宫产术中减少失血的有效性。材料与方法：该干预，随机，平行小组研究在美国医学部进行。 2014年6月至2015年5月，PSG IMSR，Coimbatore的妇产科。该手术是针对120例接受剖腹产的妇女进行的。通过计算机生成的随机数表将它们分配给研究组或对照组。除常规护理{婴儿分娩后不久向静脉滴注添加10单位催产素}外，研究组在手术前给予TXA，而对照组仅接受常规护理。通过重量分析法测量两组的失血量。统计分析：主要结局指标为手术前后的失血量和血红蛋白下降百分比。次要结果是手术时间，失血量大于500毫升的受试者比例，是否需要其他子宫收缩剂和副作用。结果：从胎盘分娩到手术结束的失血量明显减少：研究组为347.16ml，对照组为517.72ml（p <0.01）（p <0.01）。 ）。研究的另一个参数是手术前后血红蛋白下降的百分比，以及血红蛋白下降超过10％的受试者人数。研究组9.3％的受试者和对照组39％的受试者血红蛋白下降超过10％（p <0.01）。结论：TXA明显减少了下节段剖宫产（LSCS）期间的失血量。使用TXA与不良反应无关。因此，TXA可以安全有效地用于接受LSCS的受试者。

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