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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Utility of Tru-Cut Biopsy of Breast Lesions - An Experience in a Regional Cancer Center of a Developing Country EC36-EC39
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Utility of Tru-Cut Biopsy of Breast Lesions - An Experience in a Regional Cancer Center of a Developing Country EC36-EC39

机译：乳房病变Tru-Cut活检的实用性-在发展中国家EC36-EC39的区域癌症中心的经验

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Introduction: Tru-cut Needle Biopsy (TCB) is an integral part of triple assessment of breast cancer, which includes clinical assessment, mammography and TCB or Core Needle Biopsy (CNB). The technique is reliable, simple, and reproducible, and inexpensive, which can be adapted even for low-income group of patients and in developing countries.Aim: This study was done to establish the efficacy of TCB of palpable breast lesions in a developing country where mammography is not possible in all cases.Materials and Methods: A retrospective analysis of 892 TCBs was done in AH Regional Cancer Centre, Cuttack, Odisha, India where TCBs were performed in patients presenting to outpatient department with palpable breast lesions. The H&E stained sections were interpreted by pathologists of the same centre. Diagnosis was classified into different categories. Immunohistochemistry (IHC) for Estrogen Receptor (ER), Progesterone Receptor (PR) and Her-2eu was done and interpreted by Allred scoring system.Results: A total 892 TCBs were analysed with 23 repeat TCBs. There were 13 (1.4%) male patients. A total of 747 cases (83.6%) were diagnosed as malignant, including 735 carcinomas, nine malignant phyllodes tumour, two angiosarcoma and one case of Non-Hodgkin? Lymphoma (NHL). It was possible to diagnose special histological types such as lobular carcinoma, metaplastic carcinoma and mucinous carcinoma on TCB. A total of 21 cases were diagnosed as carcinoma on repeat biopsy. Eight of the 735 TCBs diagnosed as carcinoma were bilateral breast cancers, hence actual number of carcinoma cases were 727. IHC was done successfully on the paraffin blocks in 260 cases. In this series out of 727 patients of carcinomas 30% were in young, i.e., below 40 years of age, including four cases of carcinoma below 20 years. There were no false positive case in this study giving a specificity of 100% and sensitivity was 97%.Conclusion: TCBs are well tolerated by patients, can be done in OPDs and reduce cost. It is possible to give histological diagnosis of carcinoma, lymphoma, phyllodes tumour and sarcomas on TCBs. The paraffin blocks of TCBs can be used for IHC study which helps the oncologists for preoperative adjuvant therapy.
机译：简介：Tru-cut针头活检（TCB）是乳腺癌三重评估的组成部分，包括临床评估，乳房X线照相和TCB或核心针头活检（CNB）。该技术可靠，简单，可重复且廉价，甚至可以适用于低收入人群和发展中国家。目的：进行这项研究是为了确定发展中国家可触及乳腺病变的TCB的有效性。材料和方法：在印度奥里萨邦Cuttack的AH地区癌症中心对892例TCB进行了回顾性分析，其中TCB是在就诊有明显乳房病变的门诊患者中进行的。 H＆E染色的切片由同一中心的病理学家解释。诊断分为不同类别。对雌激素受体（ER），孕激素受体（PR）和Her-2 / neu进行了免疫组织化学（IHC），并通过Allred评分系统进行了解释。结果：对总共892个TCB进行了23个重复TCB的分析。男13例（1.4％）。总共诊断出747例（83.6％）为恶性，包括735例癌，9例恶性叶状肿瘤，2例血管肉瘤和1例非霍奇金淋巴瘤。淋巴瘤（NHL）。可以通过TCB诊断特殊的组织学类型，例如小叶癌，化生癌和粘液癌。重复活检共诊断出21例癌变。在被诊断为癌症的735个TCB中，有8个是双侧乳腺癌，因此，实际的癌症病例为727例。成功对260例石蜡块进行了IHC。在该系列中，在727名癌症患者中，有30％在年轻，即40岁以下，包括4名20岁以下的癌症。本研究中没有假阳性病例，特异性为100％，敏感性为97％。结论：患者对TCB的耐受性良好，可以在OPD中完成，并降低了成本。可以对TCB进行癌，淋巴瘤，叶状肿瘤和肉瘤的组织学诊断。 TCB的石蜡块可用于IHC研究，这有助于肿瘤学家进行术前辅助治疗。

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