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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinicopathological Characteristics and Outcomes of Diffuse Crescentic Glomerulonephritis - A Single Center Experience from Southern India OC21-OC24
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Clinicopathological Characteristics and Outcomes of Diffuse Crescentic Glomerulonephritis - A Single Center Experience from Southern India OC21-OC24

机译：弥漫性新月形肾小球肾炎的临床病理特征和结果-来自印度南部OC21-OC24的单中心经验

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Introduction: Diffuse Crescentic glomerulonephritis (CrGN) is characterized by rapidly progressive renal failure and has grave prognosis. There is significant regional and temporal variation in aetiology, prevalence and prognosis of diffuse crescentic glomerulonephritis (CrGN) with limited data available in adult Indian population.Aim: This study aims to identify the aetiology, clinico-pathological features and outcomes of diffuse CrGN in south Indian population.Materials and Methods: In this retrospective study, clinical records of all adults (>18 years) over a 5-year period (2010-2014) with a histopathological diagnosis of diffuse CrGN (>50% crescents) were reviewed. Clinical, serological, biochemical and histopathological data were collected. Follow-up data at six months including renal outcome and mortality were studied. Data was analysed using SPSS version 15.Results: There were 29 cases of diffuse CrGN accounting for an incidence of 2.9% among 1016 non-transplant kidney biopsies. The most common cause was pauci-immune crescentic GN. The median creatinine at admission was 7.2 mg/dl {(interquartile range (IR) 3.3 - 10.4)} and 75.9% of patients required haemodialysis at admission. Complete/partial recovery was seen in 34.5%. At the end of six months 31% were dialysis dependent and the mortality was 27.6%. On univariate analysis, the significant predictors of renal loss and mortality were oliguria (p=0.02), requirement of haemodialysis and serum creatinine (p=0.001) at admission (>5.5mg/dl) (p=0.003). Histopathological features did not influence the outcome in our study.Conclusion: In our cohort, the most common cause for diffuse CrGN is pauci-immune CrGN. Diffuse CrGN carries a poor prognosis. Patients with pauci-immune and AntiGBM disease have worst prognosis compared to immune complex CrGN. The presence of oliguria, high serum creatinine and requirement of haemodialysis at admission are associated with poor outcomes.
机译：简介：弥漫性新月形肾小球肾炎（CrGN）的特点是快速进行性肾衰竭，预后严重。在印度成年人群中，弥漫性新月形肾小球肾炎（CrGN）的病因，患病率和预后存在显着的区域和时间差异。印度人群。材料与方法：这项回顾性研究回顾了5年内（2010-2014年）所有成人（> 18岁）的临床记录，这些患者的组织病理学诊断为弥漫性CrGN（> 50％新月形）。收集临床，血清学，生化和组织病理学数据。研究了六个月的随访数据，包括肾结局和死亡率。使用SPSS 15版对数据进行分析。结果：在1016例非移植肾活检中，有29例弥散性CrGN病例，占2.9％。最常见的原因是免疫性新月形GN。入院时肌酐的中位数为7.2 mg / dl {（四分位间距（IR）3.3-10.4）}，入院时需要进行血液透析的患者为75.9％。完全/部分恢复为34.5％。六个月结束时，有31％的人依赖透析，死亡率为27.6％。单因素分析显示，入院时肾功能减退和死亡率的显着预测指标是少尿（p = 0.02），血液透析需要量和血清肌酐（p = 0.001）（> 5.5mg / dl）（p = 0.003）。组织病理学特征不影响本研究的结果。结论：在我们的队列中，弥漫性CrGN的最常见原因是弱免疫性CrGN。弥漫性CrGN预后较差。与免疫复合物CrGN相比，具有弱免疫和抗GBM疾病的患者预后最差。少尿，高肌酐和入院时需进行血液透析与不良预后相关。

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