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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Statin Induced Rhabdomyolysis with Non Oliguric Renal Failure:A Rare Presentation FD01-FD02
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Statin Induced Rhabdomyolysis with Non Oliguric Renal Failure:A Rare Presentation FD01-FD02

机译：他汀类药物引起的横纹肌溶解伴非尿性肾功能衰竭：一种罕见的表现FD01-FD02

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Statins are safe, well tolerated, efficient and time tested drugs for the management of hypercholesterolemia, and thus play a cardinal role in the management of patients with heart disease. Although safe in clinical practice, they are associated with adverse effects, clinically the most important and most severe being muscle related complications/myotoxicity. Rhabdomyolysis, though rare, is the most severe form of myotoxicity. The US Food and Drug Administration (USFDA) adverse event reporting system reports rate of statin induced rhabdomyolysis at 0.3-13.5 cases per 1,000,000 patients. We present a case of a 74-year-old male who presented with an acute coronary syndrome and was initiated on atorvastatin. However, patient developed atorvastatin induced rhabdomyolysis, with non oliguric renal failure, which subsequently improved on cessation of medication.
机译：他汀类药物是用于治疗高胆固醇血症的安全，耐受性良好，有效且经过时间检验的药物，因此在心脏病患者的治疗中起主要作用。尽管在临床实践中是安全的，但它们与不良反应相关，临床上最重要和最严重的是与肌肉相关的并发症/肌毒性。横纹肌溶解症虽然很少见，但却是最严重的肌毒性形式。美国食品和药物管理局（USFDA）不良事件报告系统报告他汀类药物引起的横纹肌溶解的发生率为每100万患者0.3-13.5例。我们介绍了一个患有急性冠状动脉综合征并由阿托伐他汀开始治疗的74岁男性病例。然而，患者发展出了阿托伐他汀诱导的横纹肌溶解，伴有非少尿性肾功能衰竭，随后在停药后有所改善。

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