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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic ?Clonic Seizures in Adults ? A Randomized Controlled Trial
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Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic ?Clonic Seizures in Adults ? A Randomized Controlled Trial

机译：丙戊酸与拉莫三嗪作为一线单药治疗新诊断的特发性全身性强直性成年人阵挛性癫痫发作随机对照试验

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Introduction: Idiopathic Generalized Tonic-Clonic Seizures (GTCS) are frequently encountered in adults. Their successful control is necessary to improve the quality of life of these patients. Valproic acid is a simple branched-chain carboxylic acid and lamotrigine is a phenyltriazine derivative. Opinions differ in regards to their effectiveness in idiopathic GTCS. Aim: To compare the effectiveness of valproic acid and lamotrigine in newly diagnosed adults with idiopathic generalized tonic-clonic seizures. Materials and Methods: The present prospective randomized study was conducted on 60 patients suffering from idiopathic GTCS. Thirty patients received valproic acid and rest 30 patients received lamotrigine. All patients were followed regularly monthly for one year for treatment response and adverse effects. Results: After 12 months follow-up, 76.67% patients taking valproic acid and 56.67% patients taking lamotrigine were seizure-free. Common adverse effects recorded were nausea, dyspepsia, headache and skin rash. Conclusion: Valproic acid is more effective than lamotrigine as first-line drug in the treatment of adults with newly diagnosed idiopathic generalized tonic-clonic seizures.
机译：简介：成人特发性强直性阵挛性癫痫发作（GTCS）很常见。他们的成功控制对于改善这些患者的生活质量是必要的。丙戊酸是一种简单的支链羧酸，拉莫三嗪是苯基三嗪衍生物。关于它们在特发性GTCS中的有效性方面，意见不一。目的：比较丙戊酸和拉莫三嗪在新诊断为特发性全身性强直-阵挛性癫痫发作的成人中的有效性。材料和方法：本前瞻性随机研究是针对60例特发性GTCS患者进行的。 30例患者接受丙戊酸治疗，其余30例患者接受拉莫三嗪治疗。所有患者每月定期随访一年，以了解治疗反应和不良反应。结果：随访12个月后，服用丙戊酸的患者为76.67％，服用拉莫三嗪的患者为56.67％。记录的常见不良反应为恶心，消化不良，头痛和皮疹。结论：丙戊酸比拉莫三嗪作为一线药物在新诊断为特发性全身性强直-阵挛性癫痫的成人中更有效。

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