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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Assessment of Lipid Peroxidationand Antioxidant Status in VanillicAcid Treated 7,12-Dimethylbenz[a]Anthracene Induced Hamster BuccalPouch Carcinogenesis BF01-BF04
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Assessment of Lipid Peroxidationand Antioxidant Status in VanillicAcid Treated 7,12-Dimethylbenz[a]Anthracene Induced Hamster BuccalPouch Carcinogenesis BF01-BF04

机译：香草酸处理的7,12-二甲基苯并[a]蒽诱导的仓鼠颊囊癌变BF01-BF04的脂质过氧化和抗氧化状态评估

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Introduction: Vanillic acid, a naturally occurring bioactive substance, possesses diverse pharmacological potential including free radical scavenging and anticancer properties. Excessive generation of Reactive Oxygen Species (ROS) and insufficient antioxidant potential has been involved in numerous pathological disorders, including cancer. Aim: To explore the anti-lipid peroxidative and antioxidant efficacy of vanillic acid in Dimethylbenz[a]Anthracene (DMBA) induced oral carcinogenesis. Materials and Methods: Topical application of DMBA for 14 weeks in the buccal pouch of hamsters resulted in well developed oral squamous cell carcinoma. Vanillic acid at a dosage of 200 mg/kg body weight was orally administrated to the hamsters for 14 weeks. The status of lipid peroxidation and antioxidants were measured in the plasma and buccal mucosa of hamsters using specific colorimetric methods. Results: Altered levels of lipid peroxidation by-products {Thiobarbituric Acid Reactive Substances (TBARS)} and disturbances in antioxidants status {Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx), vitamin E, vitamin C and reduced Glutathione (GSH)} were observed in the plasma and buccal mucosa tissues of hamsters treated with DMBA alone. Vanillic acid (200 mg/kg bw p.o) significantly restored the above mentioned plasma and buccal mucosa biochemical variables to near normal range in DMBA treated hamsters. Conclusion: Present findings thus confirm the anti-lipid peroxidative and antioxidant efficacy of vanillic acid in DMBA induced hamster buccal pouch carcinogenesis.
机译：简介：香草酸是一种天然生物活性物质，具有多种药理潜力，包括清除自由基和抗癌特性。活性氧（ROS）的生成过多和抗氧化剂的潜力不足已被卷入包括癌症在内的许多病理性疾病中。目的：探讨香草酸在二甲基苯并[a]蒽（DMBA）诱导的口腔癌发生中的抗脂质过氧化和抗氧化功效。材料和方法：在仓鼠颊囊中局部应用DMBA 14周可导致口腔鳞状细胞癌的发展。将200mg / kg体重的香草酸口服给药至仓鼠14周。使用特定的比色法测量仓鼠血浆和颊粘膜中脂质过氧化和抗氧化剂的状态。结果：脂质过氧化副产物{硫代巴比妥酸活性物质（TBARS）}的水平变化和抗氧化剂状态的变化{超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx），维生素E，维生素C和还原型谷胱甘肽（GSH）}在仅用DMBA处理的仓鼠的血浆和颊粘膜组织中观察到。香草酸（200 mg / kg体重p.o）在DMBA处理的仓鼠中可将上述血浆和颊粘膜生化变量显着恢复至正常范围。结论：本研究结果证实了香草酸在DMBA诱导的仓鼠颊囊癌变中的抗脂质过氧化和抗氧化功效。

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