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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Efficacy of 1% Curcuminoids as Local Application in Management of Oral Lichen Planus ? Interventional Study ZC89-ZC93
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Evaluation of Efficacy of 1% Curcuminoids as Local Application in Management of Oral Lichen Planus ? Interventional Study ZC89-ZC93

机译：1％姜黄素在口腔扁平苔藓管理中的局部应用效果评价介入研究ZC89-ZC93

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Introduction: Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disease affecting the oral cavity which has been associated with severe burning sensation which in turn affects the quality of life of the patients. Currently, the effective treatment of choice remains the use of corticosteroids. The chronicity and recalcitrant nature of the disease demand the long term use of these drugs with ensuing adverse effects. Turmeric and its active ingredient, ?curcumin?, have been found to have anti-inflammatory, antioxidant and anticancer properties. Hence, this intervention study was done to evaluate the efficacy of curcumin oral gel in the management of oral lichen planus.Aim: The study was conducted to compare the efficacy of 1% curcumin gel with the conventional mid-potent topical corticosteroid, triamcinolone acetonide 0.1% in managing the signs and symptoms of OLP.Materials and Methods: An intervention study was conducted on 75 patients diagnosed with OLP divided into three groups, Group 1 (0.1% triamcinolone acetonide oral paste thrice daily in tapering doses), Group 2 (curcumin oral gel thrice daily) and Group 3 (curcumin oral gel six times daily). The patients were analysed for the symptom (burning) and sign (erythema and ulceration) using the numerical rating score and Modified Oral Mucositis Index (MOMI) for a period of three months on a bimonthly basis. The results were analysed using Students t-test and unpaired t-test.Results: Intragroup comparison using paired t-test showed statistically significant reduction in burning sensation (p<0.001) as well as erythema and ulceration (p<0.001) in all the three groups. However, when the three groups were compared Group 1 showed the maximum reduction in burning sensation (77%) and erythema and ulceration (67%). Among the curcuminoid group, increased frequency was found to be more beneficial.Conclusion: Curcumin oral gel can bring about clinical improvements in OLP patients; however it cannot be used as a mainstay drug. Instead, it can be used as a maintenance drug after the patient is treated with an initial course of corticosteroids. Further studies with larger sample size and increased drug concentrations may be required.
机译：简介：口腔扁平苔藓（OLP）是一种影响口腔的慢性炎症性粘膜皮肤疾病，已伴有严重的烧灼感，进而影响患者的生活质量。当前，选择的有效治疗仍然是使用皮质类固醇。该疾病的慢性和顽固性要求长期使用这些药物并产生副作用。姜黄及其活性成分“姜黄素”已被发现具有抗炎，抗氧化和抗癌的特性。因此，本干预研究旨在评估姜黄素口服凝胶在口腔扁平苔藓治疗中的功效。目的：比较1％姜黄素凝胶与常规中效局部皮质类固醇激素曲安奈德0.1的疗效。材料和方法：对75名被诊断为OLP的患者进行干预研究，将其分为三组，第1组（0.1％曲安奈德口服曲安奈德，口服剂量每天三次，逐渐减少剂量），第2组（姜黄素）口服凝胶每天三次）和第3组（姜黄素口服凝胶每天六次）。使用数字评分和改良型口腔粘膜炎指数（MOMI），每三个月对患者进行一次症状（灼伤）和体征（红斑和溃疡）分析，为期三个月。结果：使用配对t检验的组内比较显示，在所有组中，烧灼感（p <0.001）以及红斑和溃疡（p <0.001）的减少均有统计学意义。三组。但是，当将这三组进行比较时，第1组的烧灼感（77％）以及红斑和溃疡（67％）的减少最大。结论：姜黄素口服凝胶剂可以改善OLP患者的临床症状;姜黄素组中增加频率更为有益。但是它不能用作主要药物。相反，在患者接受最初的皮质类固醇激素治疗后，它可以用作维持药物。可能需要进行更大样本量和更高药物浓度的进一步研究。

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