...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women
【24h】

Association between Serum Visfatin, Oxidative Stress, Inflammation and Metabolic Syndrome in Obese Premenopausal Women

机译：肥胖绝经前女性血清Visfatin，氧化应激，炎症与代谢综合征之间的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Visfatin is an adipokine secreted by visceral fat tissue that has important effects on normal insulin secretion. An association has been found between visfatin and cardiovascular risk factors and obesity. Despite its role in the production of inflammatory cytokines, the role of visfatin in the Metabolic Syndrome (MS) is still a matter of debate.Aim: To evaluate the relation between serum visfatin levels, oxidative stress markers, Interleukin-6 (IL-6) and (MS) in premenopausal obese women.Materials and Methods: The study enrolled 150 premenopausal obese women and 80 age-matched healthy non-obese controls. Serum visfatin and IL-6 levels were measured by Enzyme linked Immunosorbent Assay (ELISA). Oxidative status was assessed by Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), vitamins A and E and DNA damage was assessed by Comet assay.Results: Obese MS patients had significantly higher levels of visfatin, blood pressure levels, MDA and lower levels of TAC, A and E vitamins than the control group. DNA damage was significantly higher in obese women with MS and with a history of recurrent pre-eclampsia than controls. Multiple stepwise regressions analysis showed that log visfatin was positively correlated with MS components, IL-6 and MDA, serum lipids, DNA damage and negatively correlated with TAC and vitamin A and E. The log visfatin level of 1.56 had 76% sensitivity and 71% specificity for detecting MS in obese women with the area under the curve of 0.91.Conclusion: Significant positive correlations were observed between visfatin levels, oxidative and inflammatory markers with metabolic disturbance and pregnancy complications. These findings might emphasise the pathophysiological roles of these biomarkers in MS and pre-eclampsia and it may be useful to give treat to women in early pregnancy.
机译：Visfatin是内脏脂肪组织分泌的脂肪因子，对正常的胰岛素分泌具有重要作用。已发现visfatin与心血管危险因素和肥胖之间存在关联。尽管其在炎性细胞因子的产生中发挥了作用，但visfatin在代谢综合症（MS）中的作用仍是一个有争议的问题。目的：评估血清visfatin水平，氧化应激标志物，白介素6（材料和方法：该研究纳入了150名绝经前肥胖妇女和80名年龄匹配的健康非肥胖对照。血清visfatin和IL-6水平通过酶联免疫吸附测定（ELISA）进行测量。通过总抗氧化能力（TAC），丙二醛（MDA），维生素A和E评估氧化状态，并通过Comet分析评估DNA损伤。结果：肥胖MS患者的visfatin，血压，MDA水平明显升高并且TAC，A和E维生素水平低于对照组。患有MS且有复发性先兆子痫史的肥胖女性的DNA损伤明显高于对照组。多元逐步回归分析显示，对数visfatin与MS成分，IL-6和MDA，血脂，DNA损伤呈正相关，与TAC和维生素A和E呈负相关。对数visfatin水平为1.56时，敏感性为76％，而维生素A和E为71％。肥胖妇女的MS检测特异性在曲线下面积为0.91。结论：visfatin水平，氧化和炎症标志物与代谢紊乱和妊娠并发症之间存在显着正相关。这些发现可能强调了这些生物标志物在MS和先兆子痫中的病理生理作用，并且对怀孕初期的妇女进行治疗可能有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号