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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Improvement in Lipid Profile after Long-term Consumption of Policosanol Accompanied by Reduced Oxidation of LDL and Aortic Stiffness via CETP Inhibition in Healthy Middle-aged Women
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Improvement in Lipid Profile after Long-term Consumption of Policosanol Accompanied by Reduced Oxidation of LDL and Aortic Stiffness via CETP Inhibition in Healthy Middle-aged Women

机译：健康中年妇女长期服用波多固醇后伴随着低脂蛋白的氧化和主动脉僵硬度的降低，脂蛋白水平得到改善。

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Cuban Policosanol (PCO) was reported to lower serum Total Cholesterol (TC) as well as increase High-Density LipoproteinCholesterol (HDL-C) and enhance HDL functionality. In this study, we compared changes in the blood lipid and lipoprotein proflesin hypercholesterolemic women subjects (50-year-old) who consumed policosanol for 20 weeks. At week 0, subject had high TCbut low HDL-C levels. After 20 weeks of policosanol consumption, serum TC and Triglyceride (TG) levels were reduced by 10% and44%, respectively. HDL-C level was elevated 1.7-fold while Low-Density Lipoprotein (LDL) level was reduced by up to 20%. SerumCholesteryl Ester Transfer Protein (CETP) activity was reduced from 33% CE-transfer at week 0 to 22% CE-transfer at week 20.Glycation extent was signifcantly reduced in all lipoprotein fractions, especially in LDL and HDL2. In Very Low-Density Lipoprotein(VLDL) and LDL, cholesterol and TG contents were reduced. In HDL2 and HDL3, cholesterol was more enriched and TG contentreduced. LDL was more resistant to cupric ion-mediated oxidation and showed less atherogenic properties via phagocytosis intomacrophages. Apolipoprotein A-I (apoA-I) was more enriched in HDL2 and HDL3 in a time-dependent manner. The antioxidantability of HDL was enhanced by 25% in terms of ferric ion reduction ability and paraoxonase activity. In conclusion, 20 weeks ofpolicosanol consumption improved the lipid profle by increasing HDL-C, and lipoprotein functionality to enhance antioxidant, antiglycation, and anti-atherogenic properties via CETP inhibition.
机译：据报道，古巴二十烷醇（PCO）可以降低血清总胆固醇（TC）并增加高密度脂蛋白胆固醇（HDL-C）并增强HDL功能。在这项研究中，我们比较了服用二十二醇的二十四岁妇女（50岁）的血脂和脂蛋白高胆固醇血症女性受试者的变化。在第0周，受试者的TC较高，但HDL-C水平较低。服用二十四醇后，血清TC和甘油三酸酯（TG）水平分别降低了10％和44％。 HDL-C水平提高了1.7倍，而低密度脂蛋白（LDL）水平降低了20％。血清胆固醇酯转移蛋白（CETP）活性从第0周的33％CE转移降低到第20周的22％CE转移，所有脂蛋白组分中的糖基化程度均显着降低，尤其是在LDL和HDL2中。在极低密度脂蛋白（VLDL）和LDL中，胆固醇和TG含量降低。在HDL2和HDL3中，胆固醇含量更高，TG含量降低。 LDL对铜离子介导的氧化反应更具抵抗力，并且通过吞噬作用进入巨噬细胞而显示出较少的动脉粥样硬化特性。载脂蛋白A-I（apoA-I）在HDL2和HDL3中的含量呈时间依赖性。在铁离子还原能力和对氧磷酶活性方面，HDL的抗氧化能力提高了25％。总之，服用20周的二十二烷醇可以通过增加HDL-C来改善脂质分布，并且脂蛋白功能可以通过CETP抑制作用来增强抗氧化，抗糖化和抗动脉粥样硬化特性。

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