...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Region Specific Reference Intervals for TSH in the First Trimester of Pregnancy: A Three Year Retrospective Study
【24h】

Region Specific Reference Intervals for TSH in the First Trimester of Pregnancy: A Three Year Retrospective Study

机译：孕早期TSH的区域特定参考间隔：一项三年回顾性研究。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alterations in thyroid hormones levels affect maternal health and fetal neurocognitive development. Variation in geophysical and socio-economic factors, and placental Human Chorionic gonadotropin (hCG) influence thyroid hormone secretion, and decreases Thyroid Stimulating Hormone (TSH) levels. Therefore, American Thyroid Association (ATA) recommends establishment of trimester and region-specific ranges for better detection and management of thyroid hormone dysfunction.Aim: To determine the region-specific TSH values in the first trimester of pregnancy.Materials and Methods: In the three-year retrospective study, serum TSH levels of 1221 healthy pregnant women attending the antenatal OPD at GITAM Institute of Medical Sciences and Research, Visakhapatnam, Andhra Pradesh, India, were measured by the Electrochemiluminescence Immunoassay ?ECLIA?. Reference interval of TSH was calculated using the Statistical Package for the Social Sciences (SPSS) software by applying the non-parametric statistical method. The central 95% intervals (normal range), the 90% confidence intervals and the confidence ratios were calculated.Results: For TSH levels in the first trimester, the central 95% intervals were 0.43-4.5 mU/L, 90% confidence intervals were 0.27-0.45 (Upper Limit), 3.9-4.84 (Lower Limit) and the confidence ratio was 0.24. These values were found to be slightly higher than the ATA 2017 guidelines.Conclusion: Our region-specific reference interval for TSH was found to be 0.43-4.5 mU/L. The established region-specific reference intervals will help assessment of TSH levels in the first trimester of pregnancy and thereby prevent misdiagnosis and inadequate treatment.
机译：甲状腺激素水平的变化会影响产妇的健康和胎儿的神经认知发育。地球物理和社会经济因素的变化以及胎盘人类绒毛膜促性腺激素（hCG）会影响甲状腺激素的分泌，并降低甲状腺刺激激素（TSH）的水平。因此，美国甲状腺协会（ATA）建议建立三个月和特定于区域的范围，以便更好地检测和管理甲状腺激素功能障碍。目的：确定妊娠前三个月的特定于区域的TSH值。材料和方法：在为期三年的回顾性研究中，通过电化学发光免疫分析法（ECLIA）测量了印度安得拉邦维沙卡帕特南的GITAM医学科学研究所的1221名健康孕妇的血清TSH水平。使用非参数统计方法，使用社会科学统计软件包（SPSS）软件计算TSH的参考间隔。计算出中心95％区间（正常范围），90％置信区间和置信度比。结果：对于头三个月的TSH水平，中心95％区间为0.43-4.5 mU / L，90％置信区间为0.27-0.45（上限），3.9-4.84（下限），置信度为0.24。发现这些值略高于ATA 2017指南。结论：我们发现，TSH的区域特定参考间隔为0.43-4.5 mU / L。确定的区域特定参考间隔将有助于评估妊娠头三个月的TSH水平，从而防止误诊和治疗不足。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号