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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Efficacy of Low Dose (25 mg) with High Dose Diclofenac (50 mg) in Management of Postoperative Pain after Periodontal Flap Surgery: A Randomised Clinical Trial
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Comparison of Efficacy of Low Dose (25 mg) with High Dose Diclofenac (50 mg) in Management of Postoperative Pain after Periodontal Flap Surgery: A Randomised Clinical Trial

机译：小剂量（25 mg）与大剂量双氯芬酸（50 mg）在牙周皮瓣术后术后疼痛管理中的疗效比较：一项随机临床试验

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The perception of pain is highly subjective and varies substantially among individuals. Diclofenac is powerful NSAID and is associated with adverse effect, like gastric irritability.Aim: To compare a low dose Diclofenac (25 mg) with Diclofenac (50 mg) in postoperative pain management after periodontal flap surgeries.Materials and Methods: Study included 20 patients with chronic periodontitis (17-55 years), scheduled for open flap debridement surgery on at least two quadrants >1 week apart. Study was being divided into two groups One group received low dose Diclofenac (25 mg Diclofenacand 325 mg paracetamol), BID for three days, whereas the other group received Diclofenac (50 mg Diclofenac and 325 mg paracetamol), BID for three days. The pain assessment of the subjects was carried out by VAS and pain assessment questionnaire.Results: The mean pain scores in both groups were obtained by VAS After comparing those pain scores of both groups by independent t-test and repeated measures of ANOVA test, statistically significant (p<0.05) results were found between both groups at day 1,2 and 3 but less gastric discomfort were observed with Diclofenac 25 mg group.Conclusion: Diclofenac 25 mg can be used efficiently in controlling postoperative pain after open flap debridement, especially in patients with gastric discomfort.
机译：疼痛的感觉是高度主观的，并且个体之间差异很大。双氯芬酸是一种强大的非甾体抗炎药（NSAID），并具有不良反应，如胃烦躁。目的：比较低剂量双氯芬酸（25 mg）和双氯芬酸（50 mg）在牙周皮瓣手术后的术后疼痛管理中的作用。方法：研究包括20例慢性牙周炎患者（17-55岁），计划在间隔至少1周的两个象限内进行开放性皮瓣清创术。研究分为两组，一组接受低剂量双氯芬酸（25 mg双氯芬酸和325 mg对乙酰氨基酚），BID 3天，而另一组接受双氯芬酸（50 mg双氯芬酸和325 mg对乙酰氨基酚），BID 3天。结果：通过VAS和疼痛评估问卷对受试者进行疼痛评估。结果：两组患者的平均疼痛评分通过VAS获得。试验，在第1,2和3天两组间均发现统计学意义（p <0.05），但双氯芬酸25 mg组的胃部不适感较小。结论：双氯芬酸25 mg可有效控制术后疼痛开放皮瓣清创术后，尤其是胃部不适的患者。

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