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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Case Report of Fosphenytoin Induced Orofacial Dyskinesia in an 11-month-old Baby with Post-encephalitic Sequelae
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A Case Report of Fosphenytoin Induced Orofacial Dyskinesia in an 11-month-old Baby with Post-encephalitic Sequelae

机译：苯妥英钠诱发脑后后遗症11个月大婴儿口面部运动障碍的一例报道

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Fosphenytoin is used as an alternative phosphate ester prodrug to intravenous phenytoin for seizure treatment. Acute orofacialdyskinesia, secondary to phenytoin treatment is very uncommon. This case report gives the details of an 11-month-old baby girl,with post encephalitic sequelae, who developed orofacial dyskinesia during treatment with fosphenytoin. She was on fosphenytoinfor the last 11 days. She presented with lip smacking movements on the 11th day of administration of fosphenytoin. At the timeof presentation of orofacial dyskinesia, she found it diffcult to keep her tongue inside her mouth and the involuntary movementssubsided following the withdrawal of the drug. In this case, it was a probable cause of the relationship between the patient’ssymptoms and the use of fosphenytoin according to the causality assessment scales such as the Naranjo scale and the WorldHealth Organisation (WHO) Uppsala Monitoring Centre causality assessment system. She had a score of six. Also, the reactionis not likely to be owing to coexisting diseases or drugs. Though fosphenytoin induced orofacial dyskinesia is infrequent, there isa need to consider the adverse effects of fosphenytoin as a differential diagnosis in all patients with a movement disorder in thecourse of fosphenytoin treatment.
机译：苯妥英钠用作静脉苯妥英钠的替代磷酸酯前药，用于癫痫发作治疗。苯妥英钠治疗后的急性口面运动障碍非常罕见。该病例报告详细介绍了一名11个月大的女婴，患有脑后遗症，在使用苯乙妥英治疗期间发生口面运动障碍。在过去的11天中，她一直在服用磷苯妥英钠。在服用磷苯妥英钠的第11天，她出现了嘴唇sm打动作。在出现口面部运动障碍时，她发现很难将舌头保持在口中，并且在停用药物后不自主运动消退了。在这种情况下，这可能是根据Naranjo量表和世界卫生组织（WHO）乌普萨拉监测中心因果关系评估系统等因果关系评估量表得出的患者症状与使用磷苯妥英之间关系的可能原因。她得了六分。同样，反应不可能是由于疾病或药物的共存。尽管磷苯妥因诱发的口面部运动障碍很少见，但仍需考虑使用磷苯妥英的不良反应作为对所有使用磷苯妥英治疗的运动障碍患者的鉴别诊断。

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