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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of DNA Damage in Type 1 Diabetes Patients
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Evaluation of DNA Damage in Type 1 Diabetes Patients

机译：1型糖尿病患者DNA损伤的评估

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DNA damage due to oxidative stress leads to progression of diabetic complications. The association between DNA damage and diabetes mellitus has prompted to study the extent of DNA damage and factors affecting this health problem in Type 1 Diabetes (T1D).Aim: To assess serum 8-hydroxy 2?deoxyguanosine (8-OHdG) levels as a DNA damage biomarker in T1D patients.Materials and Methods: The study was carried out between September 2017 and March 2018 at Duhok Diabetes Center, Duhok, Kurdistan Region (Iraq). Serum 8-OHdG levels of 132 T1D patients and 123 age and sex matched healthy control subjects were estimated using ELISA technique. The Insulin Autoantibodies (IAA), Islets Cell Antibodies (ICA) and Glutamic Acid Decarboxylase Antibodies (GADA) were assessed in T1D patients.Results: The results revealed that serum 8-OHdG levels were significantly raised in patients (6.02±2.05 ng/mL) as compared to healthy controls (2.03±1.63 ng/mL) (p<0.01). Mean 8-OHdG was also found to be significantly higher in patients with autoantibodies (6.20±2.12 ng/mL) as compared to patients without autoantibodies (5.7±1.93 ng/mL) (p=0.04). Moreover, the prevalence of DNA damage was found to be significantly higher in patients with autoantibodies (79.3%) as compared to patients without autoantibodies (40.0%) (p=0.02).Conclusion: The present study has indicated that DNA damage accompanied by autoantibodies is highly exhibited in patients with T1D. Antioxidant supplementation may be an effective public heath intervention to reduce DNA damage and oxidative stress.
机译：氧化应激导致的DNA损伤导致糖尿病并发症的发展。 DNA损伤与糖尿病之间的关联促使研究1型糖尿病（T1D）中DNA损伤的程度和影响该健康问题的因素。目标：评估血清8-羟基2？脱氧鸟苷（8-OHdG） 材料与方法：该研究于2017年9月至2018年3月在库尔德斯坦地区（伊拉克）杜霍克的杜霍克糖尿病中心进行。使用ELISA技术评估了132位T1D患者和123位年龄和性别相匹配的健康对照受试者的血清8-OHdG水平。评估了T1D患者的胰岛素自身抗体（IAA），胰岛细胞抗体（ICA）和谷氨酸脱羧酶抗体（GADA）。 ng / mL）（2.03±1.63 ng / mL）（p <0.01）。与没有自身抗体的患者（5.7±1.93 ng / mL）相比，具有自身抗体的患者（6.20±2.12 ng / mL）的平均8-OHdG也显着更高（p = 0.04）。此外，发现具有自身抗体的患者的DNA损伤的患病率（79.3％）比没有自身抗体的患者（40.0％）（p = 0.02）显着更高。结论：本研究表明DNA损伤伴有自身抗体的T1D患者高发。补充抗氧化剂可能是减少DNA损伤和氧化应激的有效公共健康干预措施。

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