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首页> 外文期刊>Journal of bacteriology >UTILIZATION OF NITRATE BY PATHOGENIC AND SAPROPHYTIC MYCOBACTERIA
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UTILIZATION OF NITRATE BY PATHOGENIC AND SAPROPHYTIC MYCOBACTERIA

机译：病原菌和腐生菌对硝酸盐的利用

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Hedgecock, L. W. (Veterans Administration Hospital, Kansas City, Mo.) and R. L. Costello. Utilization of nitrate by pathogenic and saprophytic mycobacteria. J. Bacteriol. >84:195–205. 1962—The ability of mycobacteria to utilize nitrate as a sole source of nitrogen was examined. Nitrate-nitrogen was readily utilized by Mycobacterium butyricum, M. smegmatis, and M. tuberculosis H37Ra. Nitrate and nitrite were both utilized as sole sources of nitrogen by M. tuberculosis H37Rv. The saprophytes and drug-resistant strains of tubercle bacilli failed to reduce nitrate after having been cultured repeatedly and stored in Kirchner medium. It was necessary to add molybdenum to Kirchner medium for continued nitrate reduction by the saprophytic mycobacteria, but not for M. tuberculosis. Nitrate reductase of M. tuberculosis was inhibited by tungstate; the inhibition was reversed by molybdate at a concentration of 1:10,000. Optimal conditions for the reduction of nitrate by washed whole cells and by a particulate sonictreated extract of M. tuberculosis were studied. Reduced diphosphopyridine nucleotide was required for reduction of nitrate by the cell extract. Nitrate reduction was inhibited by isoniazid but not by p-aminosalicylic acid or streptomycin.
机译：Hedgecock，L. W.（密苏里州堪萨斯城退伍军人管理医院）和R. L. Costello。致病和腐生分枝杆菌对硝酸盐的利用。 J.细菌。 > 84： 195–205。 1962年—研究了分枝杆菌利用硝酸盐作为唯一氮源的能力。丁酸分枝杆菌，耻垢分枝杆菌和 M易于利用硝酸盐氮。结核病 H37Ra。硝酸盐和亚硝酸盐都被 M用作唯一的氮源。结核 H37Rv。反复培养并保存在Kirchner培养基中后，结核杆菌的腐生菌和耐药菌株无法还原硝酸盐。有必要向Kirchner培养基中添加钼，以通过腐生分枝杆菌持续减少硝酸盐的含量，但对于 M则不需要。结核病。硝酸盐还原酶。钨酸盐可抑制结核;钼酸盐以1：10,000的浓​​度逆转了抑制作用。通过洗涤的全细胞和经微粒处理的 M硝酸盐还原硝酸盐的最佳条件。研究了结核病。需要还原的二磷酸吡啶核苷酸来减少细胞提取物中的硝酸盐。异烟肼可抑制硝酸盐的还原，而 p -氨基水杨酸或链霉素则不能。

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