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首页> 外文期刊>Journal of bacteriology >IMMUNOCHEMISTRY OF THE PNEUMOCOCCAL TYPES II, V, AND VI III. Tests with Derivatives of the Specific Polysaccharides of Types II and VI
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IMMUNOCHEMISTRY OF THE PNEUMOCOCCAL TYPES II, V, AND VI III. Tests with Derivatives of the Specific Polysaccharides of Types II and VI

机译：II型，V型和VI型肺炎球菌的免疫化学。用II型和VI型特定多糖的衍生物进行测试

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Rebers, P. A. (Rutgers, The State University, New Brunswick, N. J.), E. Hurwitz, M. Heidelberger, and S. Estrada-Parra. Immunochemistry of the pneumococcal types II, V, and VI. III. Tests with derivatives of the specific polysaccharides of types II and VI. J. Bacteriol. >83:335–342. 1962.—The type-specific pneumococcal polysaccharides, S II and S VI, were oxidized with periodate, and the capacity of the derivatives for precipitation by antibodies and adsorption by erythrocytes was studied. The derivatives were further modified by reduction, oxidation, and condensation with urea. Oxidation of S VI with periodate reduced its precipitation of homologous antibodies much less than did similar treatment of S II. About one-half of the components are attacked in both cases, but in S II, glucuronic acid end groups, the chief determinants of specificity, are destroyed by periodate, whereas in S VI, the structures responsible for specificity are either less affected or yield derivatives with almost as much affinity for antibody as the original polysaccharide. S II and S VI are not adsorbed by washed rabbit or human erythrocytes, but their periodate-oxidized derivatives are readily taken up, presumably owing to their newly formed reactive aldehyde groups, giving high titers in passive hemagglutination. The method should be applicable to other polysaccharides which do not adsorb readily on red cells.
机译：Rebers，P. A.（罗格斯大学，州立大学，新不伦瑞克分校，新泽西州），E。Hurwitz，M。Heidelberger和S. Estrada-Parra。 II，V和VI型肺炎球菌的免疫化学。三，使用II型和VI型特定多糖的衍生物进行测试。 J.细菌。 > 83： 335-342。 1962年。用高碘酸盐氧化特定类型的肺炎球菌多糖S II和S VI，并研究了衍生物通过抗体沉淀和被红细胞吸附的能力。所述衍生物通过还原，氧化和与尿素缩合而进一步改性。用高碘酸盐氧化S VI减少的同源抗体沉淀比用S II进行的类似处理要少得多。在两种情况下，大约一半的成分都受到攻击，但是在S II中，葡萄糖醛酸端基（特异性的主要决定因素）被高碘酸盐破坏，而在S VI中，负责特异性的结构受到的影响较小或产量较低。衍生物对抗体的亲和力几乎与原始多糖相同。 S II和S VI不会被洗涤的兔或人类红细胞吸附，但是它们的高碘酸盐氧化的衍生物很容易被吸收，这可能是由于它们新形成的反应性醛基，在被动血凝反应中具有很高的效价。该方法应适用于其他不易吸附在红细胞上的多糖。

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