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首页> 外文期刊>Journal of bacteriology >METABOLISM OF PHENYLALANINE-CONTAINING PEPTIDE AMIDES IN ESCHERICHIA COLI
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METABOLISM OF PHENYLALANINE-CONTAINING PEPTIDE AMIDES IN ESCHERICHIA COLI

机译：大肠埃希菌中含苯丙氨酸的肽酰胺的代谢

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Simmonds, Sofia (Yale University, New Haven, Conn.) and David D. Griffith. Metabolism of phenylalanine-containing peptide amides in Escherichia coli. J. Bacteriol. >83:256–263. 1962.—A study was made of the hydrolysis, by fresh and lyophilized cells of a phenylalanine auxotroph of Escherichia coli, of l-phenylalanyl-glycinamide and glycyl-l-phenylalaninamide. The former dipeptide amide is hydrolyzed to yield phenylalanine and glycinamide, the latter to yield glycine and phenylalaninamide. The slow degradation of phenylalaninamide yields the free amino acid. In spite of the presence of intracellular activity toward the two dipeptide amides, neither permits as much growth as that observed with an equimolar concentration of free phenylalanine. The relatively small extent of growth on the dipeptide amides, and also on l-phenylalaninamide, appears to result from the inability of the cells in a growing culture to take up all of the exogenous amide added to the growth medium. This, in turn, probably reflects the presence in the medium of the amides as a mixture of charged and uncharged forms, of which only the latter are readily taken into the cells.
机译：索非亚的Simmonds（康涅狄格州纽黑文的耶鲁大学）和David D. Griffith。大肠杆菌中含有苯丙氨酸的肽酰胺的代谢J.细菌。 > 83： 256-263。 1962年。对新鲜的和冻干的细胞对大肠杆菌的苯丙氨酸营养缺陷型，1-苯丙氨酰-甘氨酰胺和糖基-1-苯丙氨酰胺的水解进行了研究。前者的二肽酰胺被水解产生苯丙氨酸和甘氨酰胺，后者被产生的甘氨酸和苯丙氨酰胺。苯丙氨酰胺的缓慢降解产生游离氨基酸。尽管存在针对两种二肽酰胺的细胞内活性，但它们均不允许与等摩尔浓度的游离苯丙氨酸所观察到的细胞一样多的生长。二肽酰胺以及1-苯基丙氨酰胺的相对较小程度的生长似乎是由于细胞在生长的培养物中无法吸收添加到生长培养基中的所有外源酰胺而导致的。反过来，这可能反映了酰胺在介质中以带电和不带电形式的混合物的形式存在，只有后者容易被带入细胞。

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