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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Looking Beyond LDL-Cholesterol - A Study on Extended Lipid Profile in Indian Patients with Acute Coronary Syndrome
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Looking Beyond LDL-Cholesterol - A Study on Extended Lipid Profile in Indian Patients with Acute Coronary Syndrome

机译：超越LDL胆固醇的视野-印度急性冠脉综合征患者血脂分布扩展的研究

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Assessment of dyslipidemia with only Total Cholesterol (TC), Triglyceride (TGL), Low- and High-Density Lipoprotein Cholesterol (LDL-C, HDL-C) levels, Standard Lipid Profile (SLP), leads to under-estimation of dyslipidemia as a risk factor in Acute Coronary Syndrome (ACS).Aim: To assess whether extended lipid profile gives a better risk assessment in ACS patients.Materials and Methods: In this single-centre, prospective, observational study of statin-na?ve patients presenting with ACS, SLP and Extended Lipid Profile (ELP), consisting of TC/HDL-C ratio, non-HDL-C, apolipoprotein-B, apolipoprotein-A1 and their ratio, were studied at baseline and after high-intensity statin therapy. For continuous data, descriptive statistics mean±standard deviation and also 25~(th)-75~(th) percentile was reported. Number of patients and percentages were reported for categorical data. Pearson correlation coefficient was used to find the relationship between continuous variables.Results: In the present study, 139 patients (mean age 55 years, range 21-88 years, 78% male) presented with ACS: ST-Elevation Myocardial Infarction (STEMI) 79%, non-STEMI 17%, Unstable Angina (UA) 4%. The ELP (barring non-HDL-C) showed more dyslipidemia than SLP. Dyslipidemia declined across the age spectrum from young to old and worsened across the ACS spectrum from UA to STEMI. High-intensity statin therapy reduced LDL-C significantly but not to target levels in most patients.Conclusion: ELP is better able to identify dyslipidemic risk than SLP or LDL-C alone. Dyslipidemia is more prevalent in young and STEMI patients, suggesting a greater role as risk factor in them. Achievement of target LDL-C with statin therapy remains practically elusive in most patients.
机译：仅通过总胆固醇（TC），甘油三酸酯（TGL），低密度和高密度脂蛋白胆固醇（LDL-C，HDL-C）水平，标准脂质谱（SLP）评估血脂异常会导致血脂异常的低估，因为目的：评估延长血脂水平是否能更好地评估ACS患者的风险。材料与方法：在此单中心，他汀类药物的前瞻性观察性研究在基线及之后研究了初次出现ACS，SLP和扩展脂质谱（ELP）的患者，包括TC / HDL-C比，非HDL-C，载脂蛋白B，载脂蛋白A1及其比例高强度他汀类药物治疗。对于连续数据，描述性统计的均值是±标准差，还报告了25％（th）-75％（th）百分位数。报告了患者人数和百分比以获取分类数据。结果：在本研究中，有139例ACS患者（平均年龄55岁，范围21-88岁，男性占78％）被发现：ST抬高型心肌梗死（STEMI）79％，非STEMI 17％，不稳定型心绞痛（UA）4％。 ELP（除非HDL-C以外）表现出比SLP多的血脂异常。血脂异常的年龄范围从年轻到老年人均呈下降趋势，而从UA到STEMI的ACS范围则呈恶化趋势。高强度他汀类药物疗法可在大多数患者中显着降低LDL-C，但未达到目标水平。结论：与单独使用SLP或LDL-C相比，ELP更能识别血脂异常风险。血脂异常在年轻和STEMI患者中更为普遍，表明其作为危险因素的作用更大。在大多数患者中，他汀类药物疗法无法达到目标LDL-C。

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