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首页> 外文期刊>Journal of bacteriology >Catabolic Activities of Neisseria meningitidis: Utilization of Glutamate
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Catabolic Activities of Neisseria meningitidis: Utilization of Glutamate

机译：脑膜炎奈瑟菌的分解代谢活性：谷氨酸的利用

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摘要

Glutamate was catabolized at a rapid rate by Neisseria meningitidis, group B. Surprisingly, there was a lag of 5 to 30 min in respiration, but not in CO2 production from C1, and an appreciable amount of succinate accumulated. The eventual rapid rate of respiration was not prevented by the addition of chloramphenicol. The lag period was eliminated by combinations of substrates that favored the activity of a glutamate-oxaloacetate transaminase. It is suggested that with glutamate as the sole substrate, the reaction terminated at succinate, required only moderate O2 uptake, and did not result in the transport of succinate to enzymatic sites. The lag period represented the time required for the accumulation of succinate and its transport to enzymatic sites by energy provided by the metabolism of the remaining glutamate. When the transaminase was operative, on the other hand, successive products of the reaction were immediately placed in contact with enzymatic sites.
机译：B组脑膜炎奈瑟氏球菌可快速分解谷氨酸。令人惊讶的是，呼吸作用滞后5至30分钟，而C产生的CO 2 却没有 1 ，并且积累了大量的琥珀酸盐。通过添加氯霉素并不能阻止最终的快速呼吸。通过有利于谷氨酸-草酰乙酸转氨酶活性的底物的组合消除了滞后期。建议以谷氨酸为唯一底物，该反应在琥珀酸酯处终止，仅需要适度的O 2 摄取，而不导致琥珀酸酯向酶促位点的转运。滞后时间代表琥珀酸的积累及其通过剩余谷氨酸代谢所提供的能量将其运输至酶促位点所需的时间。另一方面，当转氨酶起作用时，反应的连续产物立即与酶促位点接触。

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