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首页> 外文期刊>Journal of bacteriology >Mechanism of Polymyxin B Resistance in Proteus mirabilis
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Mechanism of Polymyxin B Resistance in Proteus mirabilis

机译：奇异变形杆菌对多粘菌素B的抗性机制

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摘要

The lipids from three types of organisms—a Proteus mirabilis wild type highly resistant to polymyxin B, a polymyxin B-sensitive mutant derived from the wild type, and the wild type grown in the presence of sulfadiazine resulting in phenotypic conversion to polymyxin B sensitivity—were examined to determine the nature of polymyxin B resistance. The phospholipid compositions were nearly identical; each organism contained similar small amounts of N-methyl phosphatidylethanolamine in addition to comparable quantities of phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. the fatty acid compositions were similar in the exponential phase of growth; in the stationary phase, sulfadiazine markedly inhibited the synthesis of cyclopropane fatty acids. Liposomes prepared from the dried lipids of the three types of organisms were extensively and similarly disrupted by the polymyxin. These findings suggest that polymyxin B resistance in P. mirabilis is determined by the cell envelope which prevents access of the antibiotic to the susceptible lipid target sites.
机译：来自三种类型的生物体的脂质-一种对多粘菌素B具有高度抵抗力的 Proteus mirabilis 野生型，一种源自该野生型的对多粘菌素B敏感的突变体以及在磺胺嘧啶的存在下生长的野生型脂质从表型转化为多粘菌素B敏感性-检查以确定多粘菌素B抗性的性质。磷脂的组成几乎相同。除相当数量的磷脂酰乙醇胺，磷脂酰甘油和心磷脂外，每种生物均包含相似量的 N -甲基磷脂酰乙醇胺。在指数生长期，脂肪酸组成相似。在固定相中，磺胺嘧啶显着抑制环丙烷脂肪酸的合成。由三种类型生物体的干燥脂质制备的脂质体被多粘菌素广泛且类似地破坏。这些发现表明 P中的多粘菌素B抗性。奇异菌是由细胞膜决定的，该细胞膜可防止抗生素进入易感脂质靶位。

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