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首页> 外文期刊>Journal of bacteriology >Expression of a mutation affecting F incompatibility in the integrated but not the autonomous state of F.
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Expression of a mutation affecting F incompatibility in the integrated but not the autonomous state of F.

机译：在F的整合状态而非自主状态下影响F不相容性的突变表达。

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摘要

Previously we have described a mutant Hfr strain in which incompatibility between the integrated F factor and an autonomous F-prime (F') factor was abolished. The mutation (inc) was located in the integrated F factor. F-prime factors isolated from the mutant Hfr strain have the same incompatibility behavior as those isolated from normal Hfr strains. Reintegration of these F' factors into the chromosome restores the Inc- phenotype characteristic of the mutant Hfr. The inc mutation thus affects incompatibility between integrated F and autonomous F(Fi-Fa incompatibility) but not incompatibility between two autonomous F factors (Fa-Fa incompatibility). The implications of this finding for the mechanism of plasmid incompatibility are discussed.
机译：以前我们已经描述了一个突变的Hfr菌株，其中消除了整合F因子和自主F-prime（F'）因子之间的不相容性。突变（inc）位于整合的F因子中。从突变Hfr菌株分离的F-prime因子与从正常Hfr菌株分离的F-prime因子具有相同的不相容性。这些F'因子重新整合入染色体可恢复突变型Hfr的Inc-表型特征。因此，inc突变影响整合的F和自主F之间的不兼容（Fi-Fa不兼容），但不影响两个自主F因子之间的不兼容（Fa-Fa不兼容）。讨论了这一发现对质粒不相容机制的意义。

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