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首页> 外文期刊>Journal of bacteriology >Nitrogen metabolite repression of nitrate reductase in Neurospora crassa.
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Nitrogen metabolite repression of nitrate reductase in Neurospora crassa.

机译：氮芥中硝酸盐还原酶的氮代谢物抑制

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摘要

The effect of different nitrogen compounds on the induction of reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase was examined in Neurospora crassa. Whereas in the wild-type strain several amino acids and ammonia inhibit the formation of nitrate reductase, only glutamine, cysteine, and histidine are shown to inhibit the synthesis of nitrate reductase in a glutamine-requiring auxotroph. None of the amino acids inhibited nitrate reductase activity in vitro. The effects of cysteine and histidine are nonspecific, these amino acids being inhibitory of the growth of the organism. The effect of glutamine on the induction of nitrate reductase is not due to an inhibition of the uptake of the inducer nitrate. By the use of histidine-, pyrimidine-, and arginine-requiring auxotrophs, it was shown that glutamine appears to act per se and does not seem to be converted to another product in order to be effective in repression. The repression of nitrate reductase by ammonia appears, from the results described herein, to be indirect; ammonia has to be converted first to glutamine in order to be effective in repression.
机译：在Neurospora crassa中检查了不同氮化合物对烟酰胺腺嘌呤二核苷酸磷酸-硝酸盐还原酶还原的影响。在野生型菌株中，几种氨基酸和氨会抑制硝酸还原酶的形成，而只有谷氨酰胺，半胱氨酸和组氨酸被显示出在需要谷氨酰胺的营养缺陷型中抑制硝酸还原酶的合成。在体外，没有一种氨基酸能抑制硝酸还原酶的活性。半胱氨酸和组氨酸的作用是非特异性的，这些氨基酸抑制生物的生长。谷氨酰胺对硝酸盐还原酶的诱导作用不是由于抑制硝酸盐诱导剂的摄取。通过使用需要组氨酸，嘧啶和精氨酸的营养缺陷型，显示出谷氨酰胺本身似乎起作用，并且似乎没有转化成另一种产物以有效地抑制。从本文所述的结果看来，氨对硝酸还原酶的抑制是间接的;反之，这是间接的。必须先将氨转化为谷氨酰胺才能有效抑制。

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