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首页> 外文期刊>Journal of bacteriology >Metabolism of pyrimidine bases and nucleosides in Bacillus subtilis.
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Metabolism of pyrimidine bases and nucleosides in Bacillus subtilis.

机译：枯草芽孢杆菌中嘧啶碱基和核苷的代谢。

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摘要

In Bacillus subtilis, uracil (Ura), uridine (Urd), and deoxyuridine (dUrd) are metabolized through pathways similar to those of enteric bacteria. Ura is probably converted to uridine 5'-monophosphate by uridine 5'-monophosphate pyrophosphorylase. More than 95% of dUrd added to cultures is converted to Ura and deoxyribose-1-phosphate. Although dUrd kinase activity is detectable in vitro, this enzyme does not seem to play an important role in the metabolism of dUrd. The metabolism of cytosine (Cyt), cytidine (Cyd), and deoxycytidine (dCyd) in B. subtilis appears to be different from that in enteric bacteria. Cytosine cannot be used by Ura-requiring mutants as pyrimidine source. dCyd is deaminated by dCyd-Cyd deaminase or phosphorylated to dCyd nucleotides by dCyd kinase. Cyd is deaminated by dCyd-Cyd deaminase of phosphorylated by Cyd kinase. This Cyd kinase activity has never been reported for B. subtilis.
机译：在枯草芽孢杆菌中，尿嘧啶（Ura），尿苷（Urd）和脱氧尿苷（dUrd）通过类似于肠细菌的途径代谢。尿苷可能被尿苷5'-单磷酸焦磷酸化酶转化为尿苷5'-单磷酸。添加到培养物中的dUrd中超过95％转化为Ura和1磷酸脱氧核糖。尽管在体外可检测到dUrd激酶的活性，但该酶似乎在dUrd的代谢中不发挥重要作用。枯草芽孢杆菌中胞嘧啶（Cyt），胞苷（Cyd）和脱氧胞苷（dCyd）的代谢似乎与肠细菌中的不同。需要尿素的突变体不能将胞嘧啶用作嘧啶源。 dCyd由dCyd-Cyd脱氨酶脱氨或被dCyd激酶磷酸化为dCyd核苷酸。 Cyd通过被Cyd激酶磷酸化的dCyd-Cyd脱氨酶脱氨基。从未报道过枯草芽孢杆菌具有这种Cyd激酶活性。

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