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首页> 外文期刊>Journal of bacteriology >EFFECT OF VACCINES PREPARED FROM HISTOPLASMA CAPSULATUM AND OTHER YEASTS ON EXPERIMENTAL TUBERCULOSIS
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EFFECT OF VACCINES PREPARED FROM HISTOPLASMA CAPSULATUM AND OTHER YEASTS ON EXPERIMENTAL TUBERCULOSIS

机译：牛膝皮肤及其他药物制备的疫苗对实验性肺结核的影响

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Hedgecock, Loyd W. (Veterans Administration Hospital, Kansas City, Mo.). Effect of vaccines prepared from Histoplasma capsulatum and other yeasts on experimental tuberculosis. J. Bacteriol. >82:115–123. 1961.—Resistance to experimental tuberculosis was enhanced by the injection of a nonviable vaccine prepared from Histoplasma capsulatum in the mycelial phase but not by the organism in the yeast phase. Acquired resistance was established within 7 days or less and usually maintained for at least 29 days. When both mycelium vaccine of H. capsulatum and a vaccine prepared from tubercle bacilli were utilized in vaccination, the results were additive (in terms of acquired resistance) provided that an interval of 3 weeks was maintained between injection of each of the vaccines. Resistance to tuberculosis was also demonstrable 14 days after the injection of nonviable preparations of Brucella abortus and Cryptococcus neoformans, as well as by yeast and mycelial vaccines of Blastomyces dermatitidis and Sporotrichum schenckii. Resistance decreased significantly when the animals were challenged 29 days after vaccination, with the exception of those injected with the yeast phase of B. dermatitidis.
机译：Hedgecock，Loyd W.（密苏里州堪萨斯城退伍军人管理局医院）。用荚膜组织胞浆菌和其他酵母菌制备的疫苗对实验性结核病的影响。 J.细菌。 > 82： 115-123。 1961年。通过在菌丝体阶段注射从荚膜组织胞膜制备的无生命疫苗增强了对实验性结核病的抵抗力，而在酵母菌阶段则没有这种疫苗。获得性抗药性在7天内或更短时间内建立，通常维持至少29天。当 H的两种菌丝体疫苗。将荚膜和由结核杆菌制备的疫苗用于疫苗接种，如果每次注射之间保持3周的间隔，则结果是累加的（就获得性耐药而言）。在注射无效的流产布鲁氏菌和新型隐球菌的制剂14天后，以及通过皮氏芽孢杆菌的酵母菌和菌丝体疫苗注射，也证实了对结核病的耐药性/ em>和 Sporotrichum schenckii 。接种疫苗29天后攻击动物时，抗性显着降低，但注射了酵母菌B的动物除外。皮肤炎。

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