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首页> 外文期刊>Journal of bacteriology >Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe.
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Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe.

机译：裂变酵母粟酒裂殖酵母细胞分裂周期突变体中的不受控制的分隔。

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A temperature-sensitive Schizosaccharomyces pombe mutant, cdc16-116, has been isolated which undergoes uncontrolled septation during its cell division cycle. The mutant accumulates two types of cells after 3 h of growth at the restrictive temperature: (i) type I cells (85% of the population), which complete nuclear division and then form up to five septa between the divided nuclei; and (ii) type II cells (15% of the population), which form an asymmetrically situated septum in the absence of any nuclear division. cdc16-116 is a monogenic recessive mutation unlinked to any previously known cdc gene of S. pombe. It is not affected in a previously reported control by which septation is dependent upon completion of nuclear division. We propose the cdc16-116 is unable to complete septum formation and proceed to cell separation and is also defective in a control which prevents the manufacture of more than one septum in each cell cycle.
机译：已分离出对温度敏感的粟酒裂殖酵母突变体cdc16-116，该突变体在其细胞分裂周期中经历了不受控制的分离。该突变体在限制性温度下生长3小时后会累积两种类型的细胞：（i）I型细胞（占种群的85％），它们完成核分裂，然后在分裂的核之间形成多达五个间隔; （ii）II型细胞（占总人口的15％），在没有任何核分裂的情况下形成不对称定位的隔膜。 cdc16-116是单基因隐性突变，与粟酒裂殖酵母的任何先前已知的cdc基因无关。它不受先前报道的控制的影响，分隔取决于分隔是否完成核分裂。我们提出，cdc16-116无法完成隔垫的形成并无法进行细胞分离，并且在控制中存在缺陷，这种对照会阻止每个细胞周期中多个隔垫的制造。

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