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首页> 外文期刊>Journal of bacteriology >Catabolism of tryptophan, anthranilate, and 2,3-dihydroxybenzoate in Trichosporon cutaneum.
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Catabolism of tryptophan, anthranilate, and 2,3-dihydroxybenzoate in Trichosporon cutaneum.

机译：色曲霉中色氨酸，邻氨基苯甲酸酯和2,3-二羟基苯甲酸酯的分解代谢

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摘要

Trichosporon cutaneum degraded L-tryptophan by a reaction sequence that included L-kynurenine, anthranilate, 2,3-dihydroxybenzoate, catechol, and beta-ketoadipate as catabolites. All of the enzymes of the sequence were induced by both L-tryptophan and salicylate, and those for oxidizing kynurenine and its catabolites were induced by anthranilate but not by benzoate; induction was not coordinate. Molecular weights of 66,100 and 36,500 were determined, respectively, for purified 2,3-dihydroxybenzoate decarboxylase and its single subunit. Substrates for this enzyme were restricted to benzoic acids substituted with hydroxyl groups at C-2 and C-3; no added coenzyme was required for activity. Partially purified anthranilate hydroxylase (deaminating) catalyzed the incorporation of one atom of 18O, derived from either 18O2 or H2(18)O, into 2,3-dihydroxybenzoic acid.
机译：毛滴霉通过包括L-犬尿氨酸，邻氨基苯甲酸酯，2，3-二羟基苯甲酸酯，儿茶酚和β-酮己二酸酯作为分解代谢物的反应序列降解了L-色氨酸。 L-色氨酸和水杨酸都诱导了该序列的所有酶，而邻氨基苯甲酸而不是苯甲酸酯诱导了氧化犬尿氨酸及其分解代谢的酶。归纳不协调。测定纯化的2，3-二羟基苯甲酸酯脱羧酶及其单个亚基的分子量分别为66,100和36,500。该酶的底物仅限于在C-2和C-3处被羟基取代的苯甲酸;不需要添加辅酶来进行活性。部分纯化的邻氨基苯甲酸酯羟化酶（脱氨）催化将一个源自18O2或H2（18）O的18O原子掺入2,3-二羟基苯甲酸中。

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