...
首页> 外文期刊>Journal of bacteriology >Defective synthesis of lipid intermediates for peptidoglycan formation in a stabilized L-form of Streptococcus pyogenes.
【24h】

Defective synthesis of lipid intermediates for peptidoglycan formation in a stabilized L-form of Streptococcus pyogenes.

机译:化脓性链球菌稳定L形式的肽聚糖形成脂质中间体的缺陷合成。

获取原文
           

摘要

Membrane preparations obtained from a stabilized L-form of Streptococcus pyogenes are incapable of synthesizing peptidoglycan from uridine-5'-diphospho-N-acetyl-D-muramyl-L-Ala-D-iso-Glu-L-Lys-D-Ala-D-Ala and uridine-5'-diphospho-N-acetyl-D-glucosamine, in contrast with similar preparations from the parental streptococcus. Furthermore, 50-fold higher levels of lipid intermediates which serve as membrane-bound substrates for peptidoglycan synthesis are synthesized in reaction mixtures containing streptococcal membranes than with similar preparations from the L-form. These observations suggest that the inability of this stabilized L-form to form a cell wall in vivo lies, at least in part, in its failure to synthesize significant quantities of the lipid substrates for peptidoglycan synthesis.
机译:从化脓性链球菌的稳定L型获得的膜制剂不能从尿苷5'-二磷酸-N-乙酰基-D-村酰胺-L-丙氨酸-异-Glu-L-Lys-D-丙氨酸合成肽聚糖。 -D-Ala和尿苷5'-二磷酸-N-乙酰基-D-葡萄糖胺,与亲本链球菌的类似制剂相反。此外,在含有链球菌膜的反应混合物中,与肽类似的L型制剂相比,合成的肽中间产物的水平高50倍,这些中间体是肽聚糖合成的膜结合底物。这些观察结果表明,这种稳定的L-型不能在体内形成细胞壁至少部分原因在于其不能合成大量的用于肽聚糖合成的脂质底物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号