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首页> 外文期刊>Journal of bacteriology >Nicotinamide adenine dinucleotide metabolism in Candida albicans.
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Nicotinamide adenine dinucleotide metabolism in Candida albicans.

机译：白色念珠菌中的烟酰胺腺嘌呤二核苷酸代谢。

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摘要

The functional pathways of nicotinamide adenine dinucleotide (NAD) biosynthesis and their regulation were studied in the dimorphic fungus Candida albicans. The presence of a functional endogenous pathway of NAD biosynthesis from tryptophan was demonstrated. In addition, nicotinamide served as an efficient salvage precursor for NAD biosynthesis but nicotinate was not utilized. The pathway for nicotinamide utilization involved nicotinate and nicotinate nucleotides as intermediates, suggesting that the failure to utilize nicotinate involves a transport defect. The mechanisms that regulate NAD levels during exponential growth operated to maintain constant NAD levels when NAD biosynthesis occurred exclusively from endogenous or salvage pathways or from a combination of the two. The regulation also operated such that the salvage pathway was preferentially utilized.
机译：研究了烟酰胺腺嘌呤二核苷酸（NAD）生物合成的功能途径及其调控在白色念珠菌白色念珠菌中。色氨酸的NAD生物合成的功能性内源性途径的存在得到证明。此外，烟酰胺可作为NAD生物合成的有效挽救前体，但并未利用烟酸酯。烟酰胺利用的途径涉及烟酸和烟酸核苷酸作为中间体，这表明未能利用烟酸涉及运输缺陷。当NAD生物合成仅发生于内源或挽救途径或两者结合时，在指数生长过程中调节NAD水平的机制可维持恒定的NAD水平。该规章的运作也使得抢救途径得到优先利用。

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