Involvement of mitochondrial protein synthesis in sporulation: effects of erythromycin on macromolecular synthesis, meiosis, and ascospore formation in Saccharomyces cerevisiae.

N Marmiroli; M Ferri; P P Puglisi

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Involvement of mitochondrial protein synthesis in sporulation: effects of erythromycin on macromolecular synthesis, meiosis, and ascospore formation in Saccharomyces cerevisiae.

机译：线粒体蛋白质合成参与孢子形成：红霉素对酿酒酵母中大分子合成，减数分裂和子囊孢子形成的影响。

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Cells of strain Z270 (MAT alpha/MAT alpha) of Saccharomyces cerevisiae did not undergo ascospore formation in buffered or unbuffered acetate sporulation medium in the presence of erythromycin. The drug inhibited sporulation when added within the first 6 to 8 h and affected to different extents some of the metabolic and sporulation-specific events that normally occur during this period. In sporulation medium, protein synthesis was highly sensitive to erythromycin, whereas RNA synthesis was unaffected and premeiotic DNA synthesis was partially inhibited. Intragenic recombination occurred at normal rates for the various heteroallelic loci tested, but rates of intergenic recombination were markedly reduced, and commitment to haploidization did not occur; hence, development was evidently arrested between intragenic and intergenic recombination. Cells kept for 8 h in acetate sporulation medium that were ready for sporulation in water without erythromycin failed to sporulate in water containing the drug, indicating that erythromycin can inhibit sporulation independent of acetate utilization.

机译：在存在红霉素的情况下，酿酒酵母Z270（MAT alpha / MAT alpha）菌株的细胞在缓冲或非缓冲的乙酸孢子形成培养基中均未发生子囊孢子形成。在开始的6至8小时内添加时，该药物会抑制孢子形成，并在不同程度上影响通常在此期间发生的某些代谢和孢子特异性事件。在孢子形成培养基中，蛋白质合成对红霉素高度敏感，而RNA合成未受影响，减数分裂前DNA合成受到部分抑制。各种异源等位基因座的基因内重组均以正常速率发生，但基因间重组的速率显着降低，并且未发生单倍体化。因此，显然在基因内和基因间重组之间阻止了发育。在不使用红霉素的水中可用于孢子形成的醋酸纤维形成培养基中保存8 h的细胞无法在含有该药物的水中形成孢子，这表明红霉素可以抑制孢子形成，而与醋酸盐的利用无关。

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《Journal of bacteriology》 |1983年第1期|共12页
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N Marmiroli; M Ferri; P P Puglisi;
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1. The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae. [J] . Zhao J, Lin W, Ma X, Genomics . 2010,第5期

机译：蛋白激酶Hal5p是酿酒酵母中与孢子形成和减数分裂以及麦角固醇生物合成有关的基因的锂敏感突变的高拷贝抑制因子。
2. The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae [J] . JingwenZhao, WeiLin, XuehuaMa, Genomics . 2010,第5期

机译：蛋白激酶Hal5p是酿酒酵母中涉及孢子形成和减数分裂以及麦角固醇生物合成的基因的锂敏感突变的高拷贝抑制因子。
3. The lability of the products of mitochondrial protein synthesis in Saccharomyces cerevisiae. A novel method for protein half-life determination [J] . A S Zubatov, A V Galkin, G Y Bakalkin, The biochemical journal . 1978,第3期

机译：酿酒酵母中线粒体蛋白质合成产物的不稳定性。测定蛋白质半衰期的新方法
4. Expanding the Scope of Protein Polymer Biosynthesis:Opportunities for the Synthesis of Novel Macromolecular Materials [C] . Kristi L.Kuck PMSE Symposia . 2002

机译：扩大蛋白质聚合物生物合成的范围：合成新型大分子材料的机会
5. The spindle checkpoint protein Bub3's role in mitosis and meiosis of the budding yeast Saccharomyces cerevisiae. [D] . Yang, Yang. 2016

机译：纺锤体检查点蛋白Bub3在发芽酵母酿酒酵母中的有丝分裂和减数分裂中的作用。
6. Involvement of mitochondrial protein synthesis in sporulation: effects of erythromycin on macromolecular synthesis meiosis and ascospore formation in Saccharomyces cerevisiae. [O] . N Marmiroli, M Ferri, P P Puglisi 1983

机译：线粒体蛋白质合成参与孢子形成：红霉素对酿酒酵母中大分子合成减数分裂和子囊孢子形成的影响。
7. The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae [O] . Zhao Jingwen, Lin Wei, Ma Xuehua, 2010

机译：蛋白激酶Hal5p是酿酒酵母中涉及孢子形成和减数分裂以及麦角固醇生物合成的基因的锂敏感突变的高拷贝抑制因子。

Involvement of mitochondrial protein synthesis in sporulation: effects of erythromycin on macromolecular synthesis, meiosis, and ascospore formation in Saccharomyces cerevisiae.

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