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首页> 外文期刊>Journal of bacteriology >A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein.
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A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein.

机译:鼠伤寒沙门氏菌毒力蛋白类似于小肠结肠炎耶尔森氏菌入侵蛋白和噬菌体λ外膜蛋白。

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The phoP-phoQ-regulated pagC locus is essential for full virulence and survival within macrophages of Salmonella typhimurium. The protein product, DNA sequence, and transcript of pagC were determined. The pagC locus encodes a single 188-amino-acid membrane protein that is similar to the ail-encoded eucaryotic cell invasion protein of Yersinia enterocolitica and the lom-encoded protein of bacteriophage lambda. The similarity of PagC and Ail to Lom leads us to hypothesize that Lom is a virulence protein and that bacteriophage gene transfer and lysogeny could have led to the development of proteins essential to survival within macrophages and eucaryotic cell invasion.
机译:phoP-phoQ调控的pagC基因座对于鼠伤寒沙门氏菌的巨噬细胞内的完整毒力和生存至关重要。测定了pagC的蛋白质产物,DNA序列和转录本。 pagC基因座编码一个单一的188个氨基酸的膜蛋白,该蛋白类似于所有编码小肠结肠炎耶尔森氏菌的全编码真核细胞侵袭蛋白和一个λ噬菌体的lom编码蛋白。 PagC和Ail与Lom的相似性使我们推测Lom是一种毒性蛋白,噬菌体基因的转移和溶原性可能导致了巨噬细胞和真核细胞侵袭中生存所必需的蛋白质的发展。

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