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首页> 外文期刊>Journal of bacteriology >Mechanism of lysis of Escherichia coli by ethanol and other chaotropic agents.
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Mechanism of lysis of Escherichia coli by ethanol and other chaotropic agents.

机译：乙醇和其他离液剂裂解大肠杆菌的机理。

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摘要

Ethanol has been shown to inhibit the assembly of cross-linked peptidoglycan and to induce cell lysis in Escherichia coli. These effects of ethanol appear to result from the weakening of hydrophobic interactions by ethanol rather than from the intercalation of ethanol into membranes. Other chaotropic agents also inhibited cross-linking and induced lysis. The potency of chaotropic anions with regard to this effect followed the expected chaotropic series. Antichaotropic agents, which strengthened hydrophobic interactions, antagonized ethanol-induced lysis. The weakening of hydrophobic interactions by ethanol is proposed as a general mechanism by which ethanol and other chaotropic agents could affect membrane-associated enzyme activities.
机译：乙醇已显示抑制交联肽聚糖的组装并诱导大肠杆菌中的细胞裂解。乙醇的这些作用似乎是由于乙醇疏水相互作用的减弱，而不是乙醇嵌入膜中所致。其他离液剂也抑制交联并诱导裂解。离液阴离子对这种作用的效力遵循预期的离液序列。抗离液剂增强了疏​​水相互作用，可拮抗乙醇诱导的裂解。乙醇对疏水相互作用的减弱被认为是乙醇和其他离液剂可影响膜相关酶活性的一般机理。

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