Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli.

V Damagnez; M P Doutriaux; M Radman

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Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli.

机译：大肠杆菌mutD5突变株中错配修复的饱和。

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The mutD (dnaQ) gene of Escherichia coli codes for the proofreading activity of DNA polymerase III. The very strong mutator phenotype of mutD5 strains seems to indicate that their postreplicational mismatch repair activity is also impaired. We show that the mismatch repair system of mutD5 strains is functional but saturated, presumably by the excess of DNA replication errors, since it is recovered by inhibiting chromosomal DNA replication. This recovery depends on de novo protein synthesis.

机译：大肠杆菌的mutD（dnaQ）基因编码DNA聚合酶III的校对活性。 mutD5菌株非常强的突变体表型似乎表明它们的复制后错配修复活性也受到了损害。我们显示mutD5菌株的错配修复系统是功能性的，但由于饱和的DNA复制错误而饱和，因为它是通过抑制染色体DNA复制而恢复的。这种恢复取决于从头蛋白质合成。

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《Journal of bacteriology》 |1989年第8期|共4页
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V Damagnez; M P Doutriaux; M Radman;
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中图分类微生物学;
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1. Escherichia coli mutator mutD5 is defective in the mutHLS pathway of DNA mismatch repair. [J] . R M Schaaper Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1989,第2期

机译：大肠杆菌突变体mutD5在DNA错配修复的mutHLS途径中存在缺陷。
2. Escherichia coli Strains (ndk) Lacking Nucleoside Diphosphate Kinase Are Powerful Mutators for Base Substitutions and Frameshifts in Mismatch-Repair-Deficient Strains [J] . Anh Nguyen, Annie Yeung, Erika Wolff, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2002,第1期

机译：缺乏核苷二磷酸激酶的大肠杆菌菌株（ndk）是错配修复缺陷菌株中碱基取代和移码的强大突变体。
3. Characterization of mutational specificity within the lacI gene for a mutD5 mutator strain of Escherichia coli defective in 3'----5' exonuclease (proofreading) activity. [J] . R G Fowler, R M Schaaper, B W Glickman Journal of bacteriology . 1986,第1期

机译：LACI基因突变特异性对大肠杆菌的Mutd5突变菌株的突变特异性的表征在3' - 5'外切核酸酶（校对）活性中缺陷。
4. High expression and identification of DNA mismatch repair gene mutSin Escherichia coli [C] . The Seventh China-Japan joint symposium on enzyme engineering . 2002

机译：DNA错配修复基因mutSin在大肠杆菌中的高表达与鉴定
5. The effects of mutator plasmids on the frequency of mutation to nalidixic acid resistance in Escherichia coli. [D] . Ambler, Jane Elizabeth. 1995

机译：突变质粒对大肠杆菌中萘啶酸抗性突变频率的影响。
6. Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli. [O] . V Damagnez, M P Doutriaux, M Radman 1989

机译：大肠杆菌mutD5突变株中错配修复的饱和。
7. Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli. [O] . Damagnez, V, Doutriaux, M P, Radman, M 1989

机译：大肠杆菌mutD5突变株中错配修复的饱和。
8. "Studies on the nature of the genetic material transferred during conjugation in Escherichia coli." and "Genetic and biochemical studies on the cell-free formation of tryptophan synthetase in Escherichia coli." [R] . 1963

机译：“在大肠杆菌结合过程中转移的遗传物质的性质研究。”和“在大肠杆菌中无色素形成色氨酸合成酶的遗传和生化研究”。

Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli.

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